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Pulrodemstat benzenesulfonate (Synonyms: CC-90011 benzenesulfonate; LSD1-IN-7 benzenesulfonate)
CC-90011 benzenesulfonate 是一种有效的,选择性的,可逆的和具有口服活性的赖氨酸特异性脱甲基酶-1 (LSD1) 抑制剂,IC50 为 0.25 nM。CC-90011 benzenesulfonate 对 LSD2,MOA-A 和 MAO-B 的酶抑制作用较小。CC-90011 benzenesulfonate 诱导急性髓细胞性白血病 (AML)和小细胞肺癌 (SCLC) 细胞分化,并具有有效的抗癌活性。
![Pulrodemstat benzenesulfonate Chemical Structure Pulrodemstat benzenesulfonate(Synonyms: CC-90011 benzenesulfonate; LSD1-IN-7 benzenesulfonate)](http://www.fluoroprobe.com/wp-content/uploads/2022/05/hy-129388b.gif)
Pulrodemstat benzenesulfonate Chemical Structure
CAS No. : 2097523-60-7
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥1475 | In-stock | |
5 mg | ¥1100 | In-stock | |
10 mg | ¥1800 | In-stock | |
50 mg | ¥5000 | In-stock | |
100 mg | ¥8500 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
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Pulrodemstat benzenesulfonate 相关产品
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生物活性 |
CC-90011 benzenesulfonate is a potent, selective, reversible and orally active inhibitor of lysine specific demethylase-1 (LSD1) with an IC50 of 0.25 nM. CC-90011 benzenesulfonate is less enzymatic inhibition against LSD2, MOA-A, and MAO-B. CC-90011 benzenesulfonate induces acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cells differentiation and has potent anticancer activity[1]. |
IC50 & Target |
IC50: 0.25 nM (LSD1)[1] |
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体外研究 (In Vitro) |
CC-90011 (Compound 11) shows potent induction of on-target cellular differentiation marker CD11b in THP-1 cell line with an EC50 of 7 nM, antiproliferative activity in AML kasumi-1 cells with an EC50 of 2 nM[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
CC-90011 (5 mg/kg; oral administration; daily; for 30 days; for 30 days) treatment inhibits tumor growth in patient-derived xenograft SCLC models[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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Clinical Trial |
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分子量 |
609.64 |
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Formula |
C30H29F2N5O5S |
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CAS 号 |
2097523-60-7 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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溶解性数据 |
In Vitro:
DMSO : 62.5 mg/mL (102.52 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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