上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
KN-93 phosphate 纯度: 99.69%
KN-93是钙离子/钙调蛋白依赖激酶II(CaMKII)抑制剂,能竞争性阻断钙调蛋白与对应激酶的结合,Ki为370 nM。
KN-93 phosphate Chemical Structure
CAS No. : 1913269-12-1
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥1318 | In-stock | |
1 mg | ¥500 | In-stock | |
5 mg | ¥1000 | In-stock | |
10 mg | ¥1250 | In-stock | |
50 mg | ¥5100 | In-stock | |
100 mg | 询价 | ||
200 mg | 询价 |
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KN-93 phosphate 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Kinase Inhibitor Library
- Neuronal Signaling Compound Library
- Anti-Cancer Compound Library
- Autophagy Compound Library
生物活性 |
KN-93 phosphate is a novel membrane-permeant synthetic inhibitor of purified neuronal CaMK-II, with Ki of 370 nM. |
IC50 & Target |
Ki: 370 nM (CaMK-II) |
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体外研究 (In Vitro) |
After 2 days of KN-93 treatment, 95% of cells are arrested in G1. G1 arrest is reversible; 1 day after KN-93 release, a peak of cells had progressed into S and G2-M. KN-93 also blocks cell growth stimulated by basic fibroblast growth factor, platelet-derived growth factor-BB, and epidermal growth factor in NIH 3T3 fibroblasts[1]. KN-93 inhibits the H+, K+-ATPase activity but strongly dissipates the proton gradient formed in the gastric membrane vesicles and reduces the volume of luminal space[2]. KN-93 (0.5 μM) prevents increased LV developed pressure during action potential prolongation and early afterdepolarizations. Ca2+-independent CaM kinase activity is increased during early afterdepolarizations and this increase is prevented by KN-93[3]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
599.03 |
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Formula |
C26H32ClN2O8PS |
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CAS 号 |
1913269-12-1 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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溶解性数据 |
In Vitro:
DMSO : 100 mg/mL (166.94 mM; Need ultrasonic) H2O : 50 mg/mL (83.47 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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