Quarfloxin(Synonyms: CX-3543)

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Quarfloxin (Synonyms: CX-3543) 纯度: 99.95%

Quarfloxin (CX-3543) 是一种具有抗肿瘤活性的氟喹诺酮类衍生物,其靶向抑制RNA pol I的活性,在神经母细胞瘤中的IC50 值在纳摩尔级别。Quarfloxin 干扰核糖体DNA中核蛋白与G-四重DNA结构的相互作用。

Quarfloxin(Synonyms: CX-3543)

Quarfloxin Chemical Structure

CAS No. : 865311-47-3

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1 mg ¥1500 In-stock
5 mg ¥3500 In-stock
10 mg ¥6000 In-stock
50 mg ¥10000 In-stock
100 mg ¥18000 In-stock
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Quarfloxin 相关产品

相关化合物库:

  • Drug Repurposing Compound Library Plus
  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus

生物活性

Quarfloxin (CX-3543), a fluoroquinolone derivative with antineoplastic activity, targets and inhibits RNA pol I activity, with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template[1].

IC50 & Target

RNA pol I[1].

体外研究
(In Vitro)

Quarfloxin (CX-3543) effectively inhibits the growth of neuroblastoma cells in vitro. MNA (or high c-Myc) and wt-TP53 cell lines are found to be more sensitive to Quarfloxin. Quarfloxin and induces DNA damage, p53 signaling, cell death, and cell cycle arrest in neuroblastoma cell lines[1].
Solution in vitro: Quarfloxin is suspended in DMSO to a stock of 10 mM[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

604.67

Formula

C35H33FN6O3

CAS 号

865311-47-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

H2O : 1 mg/mL (1.65 mM; ultrasonic and adjust pH to 5 with 0.1 M HCL)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.6538 mL 8.2690 mL 16.5379 mL
5 mM
10 mM

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Hald ØH, et al. Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma. Oncogene. 2018 Dec 12.

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