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Bobcat339 hydrochloride 纯度: 99.02%
Bobcat339 hydrochloride 是一种有效的、选择性的基于胞嘧啶的 TET 酶抑制剂,抑制 TET1 和 TET2 的 IC50 值分别为 33 μM 和 73 μM。Bobcat339 hydrochloride 可用于表观遗传学领域研究,并且可作为靶向 DNA 甲基化和基因转录新疗法的起点。
Bobcat339 hydrochloride Chemical Structure
CAS No. : 2436747-44-1
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥2750 | In-stock | |
5 mg | ¥2500 | In-stock | |
10 mg | ¥3500 | In-stock | |
50 mg | ¥9500 | In-stock | |
100 mg | ¥15000 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
* Please select Quantity before adding items.
Bobcat339 hydrochloride 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Epigenetics Compound Library
- Anti-Cancer Compound Library
- Reprogramming Compound Library
- Anti-Blood Cancer Compound Library
- Transcription Factor Targeted Library
- Targeted Diversity Library
生物活性 |
Bobcat339 hydrochloride is a potent and selective cytosine-based inhibitor of TET enzyme, with the IC50s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 hydrochloride is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription[1]. |
IC50 & Target |
IC50: 33 μM (TET1), 73 μM (TET2)[1] |
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体外研究 (In Vitro) |
Bobcat339 (10 μM; 24 hours) significantly reduces global 5hmC levels by inhibiting TET enzyme function in HT-22 cells[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
334.20 |
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Formula |
C16H13Cl2N3O |
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CAS 号 |
2436747-44-1 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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溶解性数据 |
In Vitro:
DMSO : 130 mg/mL (388.99 mM; Need ultrasonic) H2O : 0.1 mg/mL (0.30 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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