四环素 盐酸盐

四环素 盐酸盐

粉末

有货

四环素 盐酸盐

CAS编号 64-75-5 | 品牌:Jinpan
Tetracycline hydrochloride

MSDS

质检证书(CoA)

相似产品

  • 分子式 C22H24N2O8·HCl
  • 分子量480.9
  • Beilstein号 3844873
  • EC号 200-593-8

货号 (SKU) 包装规格 是否现货 价格 数量
T433239-20mg 20mg 期货 四环素 盐酸盐  
T433239-10mg 10mg 期货 四环素 盐酸盐  

基本信息

产品名称 四环素 盐酸盐
英文名称 Tetracycline hydrochloride
规格或纯度 粉末
生化机理 作用机制:四环素通过细胞膜中的 proin 通道被动扩散,与 30S 核糖体结合,并通过阻止氨酰基 tRNA 进入 mRNA-核糖体复合物上的受体位点来抑制蛋白质合成。它也与细菌的 50S 核糖体亚基结合,改变膜并导致细胞内成分从细菌细胞中泄漏。通过洗涤可以逆转抑制作用,这表明起到抗菌作用的是可逆结合的抗生素,而不是不可逆结合的药物。 耐药性机制:这种作用通过细胞壁通透性的丧失而失活。 抗菌谱:包括对革兰氏阳性和革兰氏阴性细菌的广泛抗菌活性。

一般描述

应用

建议以 10-20μg/ml 的量用于分子生物学应用。

制备说明

The product is freely soluble in water, soluble in methanol and ethanol but is insoluble in ether and hydrocarbons. In water, the product yields a clear, yellow-orange solution with heating and in 95% ethanol, 50 mg dissolved in 4 mL with heating yields a clear, yellow-green solution. Tetracycline is rapidly destroyed by alkali hydroxide solutions and standing water solutions become turbid due to hydrolysis and precipitation. The potency of tetracycline is reduced in solutions with pH below 2.

General Description

Chemical structure: tetracycline

Application

Tetracycline is a broad spectrum polyketide antibiotic with clinical uses in treating bacterial infections such as Rocky Mountain spotted fever, typush fever, tick fevers, Q fever, and Brill-Zinsser disease and to treat upper respiratory infections and acne. It has been used in studies of multidrug resistance and potential side effects including acute pancreatitis. It is recommended for use in cell culture applications at 10 mg/L and in molecular biology applications at 10-20 μg/ml.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

相关属性

CAS编号 64-75-5
比旋光度 -253° (C=0.5,0.1mol/L HCl)
熔点 223°C
储存温度 干燥
密度 1.177
分子量 480.9
分子式 C22H24N2O8·HCl
EC号 200-593-8
品牌 Jinpan
备注 注意: 直接在样品瓶中用无菌水 (10mg/ml) 制备储存液。储存液在 2-8°C 下保存不应超过一周;四环素在水溶液中会发生水解。