放线菌素 D 溶液 来源于链霉菌 属
来自链霉菌属，在DMSO中为2mg/mL
有货
基本信息
| 产品名称 | 放线菌素 D 溶液 来源于链霉菌 属 |
|---|---|
| 英文名称 | Actinomycin D, Ready Made Solution |
| 别名 | 更生霉素, 放线菌素 IV |
| 英文别名 | Dactinomycin, Actinomycin IV, Actinomycin D solution from Streptomyces sp. |
| 规格或纯度 | 来自链霉菌属，在DMSO中为2mg/mL |
| 生化机理 | Actinomycin D is an antineoplastic antibiotic that inhibits cell proliferation. It is a cytotoxic inducer of apoptosis against tumor cells. The compound inhibits the proliferation of cells in a nonspecific way by forming a stable complex with double-stranded DNA (via deoxyguanosine residues), thus inhibiting DNA-primed RNA synthesis. It also causes single strand breaks in DNA. Actinomycin D has been shown to be an inhibitor of the minus-strand transfer step in reverse transcription, and is therefore used in studies and suppression of HIV-replication. It has also been shown to suppress programmed cell death of PC12 cells induced by etoposide, an inhibitor of topoisomerase II. In cell culture, actinomycin D is used as a selection agent. Actinomycin D binding to yeast in ribosomal RNA has been studied. The sensitivity of various strains of E. coli to actinomycin D and the mechanism of binding has been studied. Actinomycin D is also used in molecular biology as a DNA intercalator which blocks the progression of RNA polymerases. |
一般描述
制备说明
The 2 mg/mL solution may be further diluted in an appropriate buffer prior to use.
相关属性
| CAS编号 | 50-76-0 |
|---|---|
| 熔点 | 251-253°C |
| 储存温度 | 避光 |
| 分子量 | 1255.438 |
| 分子式 | C62H86N12O16 |
| 品牌 | Jinpan |
| 备注 | 注意: Actinomycin D solutions are very sensitive to light. |
| PubChem CID | 126963444 |