上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
Fatostatin (Synonyms: 125B11) 纯度: 98.20%
Fatostatin (125B11) 是 SREBP 活化的特异性抑制剂,可抑制 SREBP-1 和 SREBP-2 的活化。Fatostatin 与 SCAP (SREBP裂解激活蛋白) 结合,抑制 SREBPs 的 ER-Golgi 易位。Fatostatin 降低了细胞中成脂基因的转录。Fatostatin 具有抗肿瘤作用,能降低 ob/ob 小鼠的高血糖。
Fatostatin Chemical Structure
CAS No. : 125256-00-0
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥726 | In-stock | |
5 mg | ¥660 | In-stock | |
10 mg | ¥1000 | In-stock | |
25 mg | ¥2200 | In-stock | |
50 mg | ¥3800 | In-stock | |
100 mg | ¥6900 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
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Fatostatin 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Metabolism/Protease Compound Library
- Anti-Cancer Compound Library
- Lipid Compound Library
- Anti-Cancer Metabolism Compound Library
- Anti-Obesity Compound Library
- Lipid Metabolism Compound Library
生物活性 |
Fatostatin (125B11), a specific inhibitor of SREBP activation, impairs the activation of SREBP-1 and SREBP-2. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin decreases the transcription of lipogenic genes in cells. Fatostatin possesses antitumor properties, and lowers hyperglycemia in ob/ob mice[1][2]. |
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体外研究 (In Vitro) |
Fatostatin (125B11) (0.1-1 μM; 3 days) inhibits the androgen-independent prostate cancer cell proliferation (IC50=0.1 μM) in an independent of the known IGF1-signaling pathway. Fatostatin inhibits insulin-induced adipogenesis of 3T3-L1 cells[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation Assay[1]
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体内研究 (In Vivo) |
Fatostatin (125B11) (30 mg/kg; 150 μL; i.p. injection; daily for 28 days) reduces adiposity, ameliorated fatty liver by reducing triglyceride (TG) storage, and lowered hyperglycemia in ob/ob mice[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
294.41 |
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Formula |
C18H18N2S |
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CAS 号 |
125256-00-0 |
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中文名称 |
脂肪抑制素 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : ≥ 27 mg/mL (91.71 mM) * “≥” means soluble, but saturation unknown. 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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