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CCR4 antagonist 3 hydrochloride 纯度: 98.59%
CCR4 antagonist 3 hydrochloride 是口服有效和选择性的 CCR4 拮抗剂。CCR4 antagonist 3 具有新颖的哌啶基-氮杂环丁烷基序,在钙流量和 CTX 分析中的 IC50 为 22 nM 和 50 nM。CCR4 antagonist 3 具有抗肿瘤活性。
CCR4 antagonist 3 hydrochloride Chemical Structure
CAS No. : 2174938-71-5
规格 | 价格 | 是否有货 | 数量 |
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5 mg | ¥11500 | In-stock | |
10 mg | 询价 | ||
50 mg | 询价 |
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CCR4 antagonist 3 hydrochloride 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
生物活性 |
CCR4 antagonist 3 hydrochloride is an orally active, potent and selective CCR4 antagonist. CCR4 antagonist 3, featuring a novel piperidinyl-azetidine motif, has IC50s of 22 nM and 50 nM in the calcium flux and CTX assay. CCR4 antagonist 3 has antitumor activity[1]. |
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IC50 & Target |
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体外研究 (In Vitro) |
CCR4 antagonist 3 (compound 38) shows no activity in a CYP450 induction assay[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
CCR4 antagonist 3 (compound 38; 50 mg/kg; PO; daily; for 40 days) significantly reduces the tumor growth[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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Formula |
C24H27Cl2N7O.xHCl |
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CAS 号 |
2174938-71-5 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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溶解性数据 |
In Vitro:
DMSO : 170 mg/mL (Need ultrasonic) In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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