上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
OP-5244 sodium
OP-5244 sodium 是一种有效和具有口服活性的 CD73 抑制剂,IC50 值为 0.25 nM。OP-5244 sodium 通过阻断腺苷的产生来逆转免疫抑制作用,具有进行癌症研究的潜力。
OP-5244 sodium Chemical Structure
规格 | 价格 | 是否有货 | 数量 |
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5 mg | ¥8500 | In-stock | |
10 mg | ¥14000 | In-stock | |
25 mg | ¥29500 | In-stock | |
50 mg | 询价 | ||
100 mg | 询价 |
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OP-5244 sodium 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
生物活性 |
OP-5244 sodium is a potent and orally active inhibitor of CD73, with an IC50 of 0.25 nM. OP-5244 sodium reverses immunosuppression through blocking of adenosine production, and has the potential for the cancer research[1]. |
IC50 & Target |
IC50: 0.25 nM (CD73)[1] |
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体外研究 (In Vitro) |
OP-5244 inhibits the production of adenosine (ADO), with an EC50 of 0.79±0.38 nM in H1568 (NSCLC) cells[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
OP-5244 (15 mg/kg/day; s.c. for 13 d) exhibits anti-tumor effects as a single agent as shown by the tumor growth inhibition in mice[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
559.87 |
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Formula |
C19H28ClN5NaO9P |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
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参考文献 |
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