Thalidomide-Piperazine-PEG1-NH2

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Thalidomide-Piperazine-PEG1-NH2 

Thalidomide-Piperazine-PEG1-NH2 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 Thalidomide 的 cereblon 配体和 1 个 linker。

Thalidomide-Piperazine-PEG1-NH2

Thalidomide-Piperazine-PEG1-NH2 Chemical Structure

CAS No. : 2357111-29-4

规格 是否有货
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Thalidomide-Piperazine-PEG1-NH2 的其他形式现货产品:

Thalidomide-Piperazine-PEG1-NH2 diTFA

生物活性

Thalidomide-Piperazine-PEG1-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

IC50 & Target

Cereblon

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

429.47

Formula

C21H27N5O5
CAS 号

2357111-29-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性数据
In Vitro: 

DMSO : 250 mg/mL (582.11 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.3285 mL 11.6423 mL 23.2845 mL
5 mM 0.4657 mL 2.3285 mL 4.6569 mL
10 mM 0.2328 mL 1.1642 mL 2.3285 mL

参考文献

  • [1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.

    [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1000.

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