Pomalidomide-amido-C1-Br

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Pomalidomide-amido-C1-Br 

Pomalidomide-amido-C1-Br 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 Pomalidomide 的 cereblon 配体和 1 个 linker。Pomalidomide-amido-C1-Br 可通过 PROTAC 技术合成 B-Raf 降解剂 PROTAC B-Raf degrader 1 (HY-111758)。PROTAC B-Raf degrader 1 具有抗肿瘤活性。

Pomalidomide-amido-C1-Br

Pomalidomide-amido-C1-Br Chemical Structure

CAS No. : 2351106-38-0

规格 价格 是否有货
5 mg ￥3500 询问价格 & 货期
50 mg ￥9500 询问价格 & 货期
100 mg ￥13500 询问价格 & 货期

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生物活性

Pomalidomide-amido-C1-Br is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker. Pomalidomide-amido-C1-Br can be used to design a B-Raf PROTAC degrader PROTAC B-Raf degrader 1 (HY-111758). PROTAC B-Raf degrader 1 has anti-cancer activity[1].

IC50 & Target[1]

Cereblon

 

体外研究
(In Vitro)

Pomalidomide-amido-C1-Br (Compound 6) can be used to design a B-Raf PROTAC degrader PROTAC B-Raf degrader 1 (Compound 2). PROTAC B-Raf degrader 1 can effectively kill cancer cells via inducing cells apoptosis. As a B-Raf degrader, PROTAC B-Raf degrader 1 can accelerate the degradation of B-Raf by recruiting ubiquitin-proteasome system, and further affects the expression of Mcl-1, a downstream protein of B-Raf[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

394.18

Formula

C15H12BrN3O5
CAS 号

2351106-38-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
参考文献

  • [1]. Chen H, et al. Pomalidomide hybrids act as proteolysis targeting chimeras: Synthesis, anticancer activity and B-Raf degradation. Bioorg Chem. 2019 Jun;87:191-199.

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