Desmorpholinyl Quizartinib-PEG2-COOH

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Desmorpholinyl Quizartinib-PEG2-COOH  纯度: 95.09%

Desmorpholinyl Quizartinib-PEG2-COOH 包含靶蛋白 FLT-3 配体和一种基于 PEG 的 PROTAC Linker。Desmorpholinyl Quizartinib-PEG2-COOH 可用于合成 PROTAC FLT-3 degrader 1 (HY-114323)。PROTAC FLT-3 degrader 1 是 PROTAC FLT-3 ITD 降解剂,IC50 为 0.6 nM。

Desmorpholinyl Quizartinib-PEG2-COOH

Desmorpholinyl Quizartinib-PEG2-COOH Chemical Structure

CAS No. : 2292116-14-2

规格 价格 是否有货 数量
50 mg ¥8500 In-stock
250 mg ¥22500 In-stock
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生物活性

Desmorpholinyl Quizartinib-PEG2-COOH incorporates a ligand for FLT-3, and a PEG-based PROTAC linker. Desmorpholinyl Quizartinib-PEG2-COOH can be used in the synthesis of PROTAC FLT-3 degrader 1 (HY-114323). PROTAC FLT-3 degrader 1 is a PROTAC FLT-3 internal tandem duplication (ITD) degrader with an IC50 0.6 nM[1].

分子量

607.68

Formula

C30H33N5O7S

CAS 号

2292116-14-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献
  • [1]. Burslem GM, et al. Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion. J Am Chem Soc. 2018 Dec 5;140(48):16428-16432.

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