Thalidomide-PEG2-C2-NH2 TFA(Synonyms: Thalidomide-NH-PEG2-C2-NH2 TFA)

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Thalidomide-PEG2-C2-NH2 TFA (Synonyms: Thalidomide-NH-PEG2-C2-NH2 TFA) 纯度: 98.85%

Thalidomide-PEG2-C2-NH2 TFA 是一种合成的 E3 连接酶配体-linker 偶联物,包含基于 Thalidomide 的 cereblon 配体和 2 个单元的 PEG linker。

Thalidomide-PEG2-C2-NH2 TFA(Synonyms: Thalidomide-NH-PEG2-C2-NH2 TFA)

Thalidomide-PEG2-C2-NH2 TFA Chemical Structure

CAS No. : 2097509-36-7

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生物活性

Thalidomide-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology[1].

IC50 & Target[1]

Cereblon

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

518.44

Formula

C21H25F3N4O8

CAS 号

2097509-36-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

参考文献
  • [1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62(17):8152-8163.

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