Saridegib(Synonyms: IPI-926; Patidegib)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Saridegib (Synonyms: IPI-926; Patidegib) 纯度: ≥99.0%

Saridegib 是 Smo 的特异性有效抑制剂，这是 Hedgehog 通路中关键的跨膜信号蛋白。

Saridegib(Synonyms: IPI-926; Patidegib)

Saridegib Chemical Structure

CAS No. : 1037210-93-7

规格 价格 是否有货
5 mg ￥23800 询问价格 & 货期

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生物活性

Saridegib is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.

IC50 & Target

Smo[1].
体内研究
(In Vivo)

Evidence from a genetically engineered mouse model of pancreatic cancer demonstrates that Saridegib (IPI-926) can deplete tumor-associated stromal tissue and increase intratumoral mean vessel density. These changes result in enhanced delivery of concurrently administered systemic agents, leading to a decreased tumor burden and prolonged survival in this mouse model[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

504.77

Formula

C29H48N2O3S
CAS 号

1037210-93-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Ko AH, et al. A Phase I Study of FOLFIRINOX Plus IPI-926, a Hedgehog Pathway Inhibitor, for Advanced Pancreatic Adenocarcinoma. Pancreas. 2016 Mar;45(3):370-5.

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