NTRC 0066-0

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

NTRC 0066-0  纯度: 98.90%

NTRC 0066-0 是一种选择性苏氨酸酪氨酸激酶 (TTK) 抑制剂 (IC50=0.9 nM)。NTRC 0066-0可用于癌症研究。

NTRC 0066-0

NTRC 0066-0 Chemical Structure

CAS No. : 1817791-73-3

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥2240 In-stock
5 mg ￥1800 In-stock
10 mg ￥2900 In-stock
25 mg ￥5800 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

NTRC 0066-0 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Kinase Inhibitor Library
  • Anti-Cancer Compound Library
  • Anti-Breast Cancer Compound Library
  • Targeted Diversity Library

生物活性

NTRC 0066-0 is a selective threonine tyrosine kinase (TTK) inhibitor (IC50=0.9 nM). NTRC 0066-0 can be used for the research of cancer[1].

IC50 & Target

IC50: 0.9 nM (TTK)[1]
体外研究
(In Vitro)

NTRC 0066-0 has a low selectivity entropy and a relatively long target residence time on TTK and inhibits the proliferation of diverse cancer cell lines with a potency in the same range as that of classic chemotherapeutic agents such as doxorubicin. NTRC 0066-0, has subnanomolar potency in a TTK enzyme assay and inhibits the proliferation of cancer cell lines from diverse tumor tissue origin with IC50 from 11 to 290 nM at 5-day incubation time[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

NTRC 0066-0 inhibited tumor growth in a mouse xenograft model of the human triple-negative breast cancer (TNBC) cell line MDA-MB-231[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

565.71

Formula

C33H39N7O2
CAS 号

1817791-73-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 20.83 mg/mL (36.82 mM; ultrasonic and warming and heat to 60°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7677 mL 8.8385 mL 17.6769 mL
5 mM 0.3535 mL 1.7677 mL 3.5354 mL
10 mM 0.1768 mL 0.8838 mL 1.7677 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Uitdehaag JCM, et al. Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity. J Mol Biol. 2017;429(14):2211-2230.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务