THP-PEG4-Pyrrolidine(N-Me)-CH2OH

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

THP-PEG4-Pyrrolidine(N-Me)-CH2OH  纯度: ≥95.0%

THP-PEG4-Pyrrolidine(N-Me)-CH2OH 是基于 PEG 结构的 PROTAC linker, 可以用来制备 PROTAC K-Ras Degrader-1 (HY-129523)。

THP-PEG4-Pyrrolidine(N-Me)-CH2OH

THP-PEG4-Pyrrolidine(N-Me)-CH2OH Chemical Structure

CAS No. : 2378261-81-3

规格 价格 是否有货 数量
100 mg ¥4500 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

THP-PEG4-Pyrrolidine(N-Me)-CH2OH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523)[1].

IC50 & Target[1]

PEGs

 

体外研究
(In Vitro)

PROTAC K-Ras Degrader-1 is potent K-Ras degrader based PROTAC, exhibits ≥70% degradation efficacy in SW1573 cells[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

391.50

Formula

C19H37NO7

CAS 号

2378261-81-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

参考文献
  • [1]. CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务