diABZI-C2-NH2

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diABZI-C2-NH2  纯度: 96.02%

diABZI-C2-NH2是一种含有伯胺功能的活性类似物,是一种 STING 激动剂。

diABZI-C2-NH2

diABZI-C2-NH2 Chemical Structure

CAS No. : 2137975-93-8

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10 mg ¥12500 In-stock
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diABZI-C2-NH2 相关产品

相关化合物库:

  • Bioactive Compound Library Plus

生物活性

diABZI-C2-NH2, an active analogue containing a primary amine functionality, is a STING agonist[1].

体外研究
(In Vitro)

The author developed a linking strategy to synergize the effect of two symmetry-related amidobenzimidazole (ABZI)-based compounds to create linked ABZIs (diABZIs) with enhanced binding to STING and cellular function. Intravenous administration of a diABZI STING agonist to immunocompetent mice with established syngeneic colon tumours elicited strong anti-tumour activity, with complete and lasting regression of tumors[1].
diABZI-C2-NH2 is covalently immobilized on sepharose beads and is used to affinity-capture potential target proteins from a THP1 cell lysate[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

721.81

Formula

C36H43N13O4

CAS 号

2137975-93-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献
  • [1]. Ramanjulu JM, et al. Design of amidobenzimidazole STING receptor agonists with systemic activity [published correction appears in Nature. 2019 Jun;570(7761):E53]. Nature. 2018;564(7736):439-443.

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