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Mutant IDH1-IN-2 纯度: 98.50%
Mutant IDH1-IN-2是一种突变型异柠檬酸脱氢酶 (IDH) 蛋白抑制剂, 在LS-MS生物化学检测中IC50值为<22 nM, 荧光生物化学检测中IC50值为16.6 nM。
Mutant IDH1-IN-2 Chemical Structure
CAS No. : 1429176-69-1
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥3030 | In-stock | |
5 mg | ¥3000 | In-stock | |
10 mg | ¥5000 | In-stock | |
25 mg | ¥9500 | In-stock | |
50 mg | ¥15500 | In-stock | |
100 mg | 询价 | ||
200 mg | 询价 |
* Please select Quantity before adding items.
Mutant IDH1-IN-2 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Metabolism/Protease Compound Library
- Anti-Cancer Compound Library
- Glutamine Metabolism Compound Library
- Anti-Cancer Metabolism Compound Library
- Mitochondria-Targeted Compound Library
- Glucose Metabolism Compound Library
- Targeted Diversity Library
生物活性 |
Mutant IDH1-IN-2 is a inhibitor of mutant Isocitrate dehydrogenase (IDH) proteins, with IC50 of in LS-MS biochemical assay, IC50 of 16.6 nM in Fluorescence biochemical assay. Target: Mutant IDH1 Mutant IDH1-IN-2 has a neomorphic activity and in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer. More bioactivity information in Patent WO 2013046136A1 (Example 224). |
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分子量 |
459.53 |
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Formula |
C24H31F2N5O2 |
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CAS 号 |
1429176-69-1 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 50 mg/mL (108.81 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
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参考文献 |
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