Lucidin(Synonyms: 卢西定 ; NSC 30546)


Lucidin (Synonyms: 卢西定 ; NSC 30546) 纯度: 97.02%

Lucidin (NSC 30546)是茜草中的天然成分,能诱导细菌和哺乳动物细胞的突变。

Lucidin(Synonyms: 卢西定 ; NSC 30546)

Lucidin Chemical Structure

CAS No. : 478-08-0

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥2635 In-stock
2 mg ¥1773 In-stock
5 mg ¥2660 In-stock
10 mg ¥3432 In-stock
50 mg ¥9263 In-stock
100 mg ¥14768 In-stock
200 mg   询价  
500 mg   询价  

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Lucidin (NSC 30546) is a natural component of Rubia tinctorum L. lucidin is mutagenic in bacteria and mammalian cells. IC50 Value: Target: in vitro: Lucidin was mutagenic in five Salmonella typhimurium strains without metabolic activation, but the mutagenicity was increased after addition of rat liver S9 mix. In V79 cells, lucidin was mutagenic at the hypoxanthine-guanine phosphoribosyl transferase gene locus and active at inducing DNA single-strand breaks and DNA-protein cross-links as assayed by the alkaline elution method. Lucidin also induced DNA repair synthesis in primary rat hepatocytes and transformed C3H/M2-mouse fibroblasts in culture [1]. HPLC analysis of 32P-labelled DNA adducts revealed a peak co-migrating with an adduct obtained after in vitro treatment of deoxyguanosine-3′-phosphate with lucidin [2]. in vivo: Dose-dependent increases in benign and malignant tumour formation were observed in the liver and kidneys of treated animals. 32P-post-labelling analysis showed an increase in the overall level of DNA adducts observed in the liver, kidney and colon of rats treated with 10% madder root in the diet for 2 weeks [2]. Toxicity: lucidin is mutagenic in bacteria and mammalian cells [2]. Clinical trial:










Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
In Vitro: 

DMSO : 6.67 mg/mL (24.68 mM; Need ultrasonic)

浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.7004 mL 18.5021 mL 37.0041 mL
5 mM 0.7401 mL 3.7004 mL 7.4008 mL
10 mM 0.3700 mL 1.8502 mL 3.7004 mL


储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

  • [1]. Westendorf J, et al. The genotoxicity of lucidin, a natural component of Rubia tinctorum L., and lucidinethylether, a component of ethanolic Rubia extracts. Cell Biol Toxicol. 1988 Jun;4(2):225-39.

    [2]. Westendorf J, et al. Carcinogenicity and DNA adduct formation observed in ACI rats after long-term treatment with madder root, Rubia tinctorum L. Carcinogenesis. 1998 Dec;19(12):2163-8.