N6-Isopentenyladenosine(Synonyms: Riboprine)

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N6-Isopentenyladenosine (Synonyms: Riboprine)

N6-Isopentenyladenosine (Riboprine),一种在细胞分裂素中发现的 RNA 修饰,可调节植物生长/分化,以及 tRNA,可提高翻译的效率和准确性。N6-Isopentenyladenosine,甲羟戊酸途径的终产物,是一种具有抗黑色素瘤活性的自噬 (autophagy) 抑制剂。

N6-Isopentenyladenosine(Synonyms: Riboprine)

N6-Isopentenyladenosine Chemical Structure

CAS No. : 7724-76-7

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N6-Isopentenyladenosine 相关产品

相关化合物库:

  • Natural Product Like Compound Library
  • Bioactive Compound Library Plus
  • Metabolism/Protease Compound Library
  • Anti-Cancer Compound Library
  • Autophagy Compound Library
  • Nucleotide Compound Library
  • Food-Sourced Compound Library

生物活性

N6-Isopentenyladenosine (Riboprine), an RNA modification found in cytokinins, which regulate plant growth/differentiation, and a subset of tRNAs, where it improves the efficiency and accuracy of translation. N6-Isopentenyladenosine, an end product of the mevalonate pathway, is an autophagy inhibitor with an interesting anti-melanoma activity[1][2][3].

体外研究
(In Vitro)

N6-isopentenyladenosine dual targeting of AMPK and Rab7 prenylation inhibits melanoma growth through the impairment of autophagic flux[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

335.36

Formula

C15H21N5O4

CAS 号

7724-76-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献
  • [1]. Colombo F, et al. Pharmacogenomics and analogues of the antitumour agent N6-isopentenyladenosine. Int J Cancer. 2009;124(9):2179-2185.

    [2]. Ranieri R, et al. N6-isopentenyladenosine dual targeting of AMPK and Rab7 prenylation inhibits melanoma growth through the impairment of autophagic flux. Cell Death Differ. 2018;25(2):353-367.

    [3]. Cheng HP, et al. Chemical Deprenylation of N6 -Isopentenyladenosine (i6 A) RNA. Angew Chem Int Ed Engl. 2020;59(26):10645-10650.

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