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Folitixorin (Synonyms: 5,10-Methylenetetrafolate; ANX-510 free acid) 纯度: ≥80.0%
Folitixorin (5,10-methylenetetrahydrofolate) 是一种辅助因子和亚叶酸的类似物。Folitixorin 是一种在辅助肿瘤研究中调节 5-FU 细胞毒性的有潜力的试剂。
Folitixorin Chemical Structure
CAS No. : 3432-99-3
| 规格 | 价格 | 是否有货 | 数量 |
|---|---|---|---|
| 1 mg | ￥2800 | In-stock | |
| 5 mg | ￥8500 | 询价 | |
| 10 mg | 询价 | ||
| 50 mg | 询价 |
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| 生物活性 |
Folitixorin (5,10-methylenetetrahydrofolate) is a cofactor and an analog of leucovorin. Folitixorin is a promising agent for modulation of 5-FU cytotoxicity in adjuvant cancer research[1][2]. |
|---|---|
| 体外研究 (In Vitro) |
5,10-methylenetetrahydrofolate reductase (MTHFR) catalyzes the conversion of 5,10-methylenetetrahydrofolate into 5-methyltetrahy-drofolate, which is the major circulating form of folate[3]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
| 体内研究 (In Vivo) |
A colon adenocarcinoma cell suspension is inoculated intrahepatically in a rodent experimental model. Intravenous 5-FU (30 mg/kg) in combination with Folitixorin (15 mg/kg or 30 mg/kg) is administered after 1, 2, 3, 4 and 7 days. 5-FU in combination with Folitixorin (regardless of folate-dose) eliminats tumor take[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
| 分子量 |
457.44 |
| Formula |
C20H23N7O6 |
| CAS 号 |
3432-99-3 |
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
-80°C, protect from light, stored under nitrogen |
| 参考文献 |
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