Lenalidomide-5-Br

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Lenalidomide-5-Br  纯度: ≥97.0%

Lenalidomide-5-Br 是一种基于 Lenalidomide 的 E3 泛素连接酶 cereblon (CRBN) 配体,用于募集 cereblon 蛋白。Lenalidomide-5-Br 可通过 linker 连接到蛋白质配体上形成 PROTAC。

Lenalidomide-5-Br

Lenalidomide-5-Br Chemical Structure

CAS No. : 1010100-26-1

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Lenalidomide-5-Br 相关产品

相关化合物库:

  • Bioactive Compound Library Plus

生物活性

Lenalidomide-5-Br is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-Br can be connected to the ligand for protein by a linker to form PROTAC[1].

IC50 & Target

Cereblon

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

323.14

Formula

C13H11BrN2O3

CAS 号

1010100-26-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble or slightly soluble)

H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

参考文献
  • [1]. Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25.

    [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

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