上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
PTP1B-IN-3 diammonium
PTP1B-IN-3 diammonium 是有效的,有选择性的 PTP1B 抑制剂,对 PTP1B 和 TCPTP 的 IC50 值均为 120 nM。PTP1B-IN-3 diammonium 具有抗糖尿病和抗癌作用。
PTP1B-IN-3 diammonium Chemical Structure
规格 | 价格 | 是否有货 | 数量 |
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1 mg | ¥9500 | In-stock | |
5 mg | 询价 | ||
10 mg | 询价 |
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生物活性 |
PTP1B-IN-3 diammonium is a potent and orally active PTP1B inhibitor with IC50s of 120 nM for both PTP1B and TCPTP. PTP1B-IN-3 diammonium has antidiabetic and anticancer effects[1][2]. |
IC50 & Target |
IC50: 120 nM (PTP1B), 120 nM (TCPTP)[2] |
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体内研究 (In Vivo) |
In diet-induced obese (DIO) mice, PTP1B-IN-3 (compounds 3g) exhibits dose dependent inhibition (60%, 80% and 100% inhibition at 1, 3 and 10 mg/kg, respectively) of glucose excursion when given orally 2 h before oral glucose challenge with an estimated ED50 of 0.8 mg/kg[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
分子量 |
396.12 |
Formula |
C12H13BrF2N3O3P |
运输条件 |
Room temperature in continental US; may vary elsewhere. |
储存方式 |
-20°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen) |
参考文献 |
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