Buclizine dihydrochloride

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Buclizine dihydrochloride  纯度: ≥98.0%

Buclizine dihydrochloride 是具有口服活性的抗组胺、抗过敏化合物。Buclizine dihydrochloride 对大鼠是一种强效的致畸剂。

Buclizine dihydrochloride

Buclizine dihydrochloride Chemical Structure

CAS No. : 129-74-8

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生物活性

Buclizine dihydrochloride is an orally active antihistamine antiallergic compound. Buclizine dihydrochloride is a potent teratogen in the rat[1][2][3].

体外研究
(In Vitro)

Buclizine (0-100 μM, 72 h) inhibits cancer cell growth by binding to TCTP and induction of cell differentiation[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[3].

Cell Line: MCF-7 cells[3].
Concentration: 0-100 μM.
Incubation Time: 72 h.
Result: The IC50 was 19.18 ± 5.32 μM.

体内研究
(In Vivo)

Buclizine dihydrochloride (≥40 mg/kg) exhibits teratogenic effect[1].
Buclizine dihydrochloride exhibits the t1/2 of ~10 h via oral administration[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eighty-seven mature female rats weighing 240±20 grams[1].
Dosage: 30-200 mg/kg.
Administration: From days 10 to 15.
Result: Exhibits teratogenic effect dose-dependently when ≥40 mg/kg.

分子量

505.95

Formula

C28H35Cl3N2
CAS 号

129-74-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro: 

DMSO : 2.5 mg/mL (4.94 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9765 mL 9.8824 mL 19.7648 mL
5 mM — — —
10 mM — — —

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. C T King, et al. Teratogenic effect of buclizine and hydroxyzine in the rat and chlorcyclizine in the mouse. Am J Obstet Gynecol. 1966 May 1;95(1):109-11.

    [2]. Nawab Sher, et al. Simultaneous determination of antihistamine anti-allergic drugs, cetirizine, domperidone, chlorphenamine maleate, loratadine, meclizine and buclizine in pharmaceutical formulations, human serum and pharmacokinetics application. Analytical methods • March 2014.

    [3]. Ean-Jeong Seo, et al. Interaction of antihistaminic drugs with human translationally controlled tumor protein (TCTP) as novel approach for differentiation therapy. Oncotarget . 2016 Mar 29;7(13):16818-39.

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