Se-Methylselenocysteine(Synonyms: Methylselenocysteine; Se-Methylseleno-L-cysteine)


Se-Methylselenocysteine (Synonyms: Methylselenocysteine; Se-Methylseleno-L-cysteine)

Se-Methylselenocysteine,甲基硒的前体,具有强大的癌症化学预防活性和抗氧化活性。Se-Methylselenocysteine 具有口服生物活性,可诱导细胞凋亡 (apoptosis)

Se-Methylselenocysteine(Synonyms: Methylselenocysteine;  Se-Methylseleno-L-cysteine)

Se-Methylselenocysteine Chemical Structure

CAS No. : 26046-90-2

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10 mM * 1 mL in Water ¥550 In-stock
5 mg ¥500 In-stock
10 mg ¥850 In-stock
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Se-Methylselenocysteine, a precursor of Methylselenol, has potent cancer chemopreventive activity and anti-oxidant activity. Se-Methylselenocysteine is orally bioavailable, and induces apoptosis[1][2].

(In Vitro)

Se-Methylselenocysteine (100-400 μM; 3 days) induces apoptosis in SKOV-33 cells[1].
Se-Methylselenocysteine (100-400 μM; 3 days) induces caspase-3 mediated apoptosis[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: SKOV-3 cells
Concentration: 100, 200, 400 μM
Incubation Time: 3 days
Result: Resulted in a markedly increased accumulation of Sub-G1 phase, which occurred in both SeMSC concentration and culture time-dependent.

Western Blot Analysis[1]

Cell Line: SKOV-3 cells
Concentration: 100, 200, 400 μM
Incubation Time: 3 days
Result: Resulted in a decrease in the expression of the 32 kDa form of procaspase-3.

(In Vivo)

Se-Methylselenocysteine (0.2 mg/mouse; p.o.; daily for 14 days) potentiates the antitumour activity of CDDP and Cyclophosphamide in nude mice bearing human FaDu and A253 head and neck xenografts[2].
Alzheimer’s disease (AD) mice are treats with Se-Methylselenocysteine (0.75 mg/kg BW per day) in their drinking water for 10 months. Se-Methylselenocysteine reduces oxidative stress and neuro-inflammation; Se-Methylselenocysteine modulates the distribution and levels of several metal ions; Se-Methylselenocysteine decreases amyloid-β peptide (Aβ) generation by inhibiting the expression of its precursor protein APP and β-secretase (BACE1), and attenuates tau hyperphosphorylation and neurofibrillary tangles (NFT) formation via promoting protein phosphatase 2A (PP2A) activity, thereby preserving synaptic proteins and neuron activities and finally improving spatial learning and memory deficits in AD model mice[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female athymic nude mice (bearing human A253 and FaDu squamous cell carcinoma xenografts)[2]
Dosage: 0.2 mg/mouse
Administration: p.o.; daily for 14 days (7 days before and 7 days after Cyclophosphamide or CDDP in a total of 14 days)

Clinical Trial








Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
In Vitro: 

H2O : 83.33 mg/mL (457.66 mM; Need ultrasonic)

浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 5.4921 mL 27.4605 mL 54.9209 mL
5 mM 1.0984 mL 5.4921 mL 10.9842 mL
10 mM 0.5492 mL 2.7460 mL 5.4921 mL


储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

  • [1]. Yeo JK, et al. Se-methylselenocysteine induces apoptosis through caspase activation and Bax cleavage mediated by calpain in SKOV-3 ovarian cancer cells. Cancer Lett. 2002 Aug 8;182(1):83-92.

    [2]. Cao S, et al. Se-methylselenocysteine offers selective protection against toxicity and potentiates the antitumour activity of anticancer drugs in preclinical animal models. Br J Cancer. 2014 Apr 2;110(7):1733-43.

    [3]. Xie Y, et al. Se-Methylselenocysteine Ameliorates Neuropathology and Cognitive Deficits by Attenuating Oxidative Stress and Metal Dyshomeostasis in Alzheimer Model Mice. Mol Nutr Food Res. 2018 Jun;62(12):e1800107.