Se-Methylselenocysteine(Synonyms: Methylselenocysteine; Se-Methylseleno-L-cysteine)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Se-Methylselenocysteine (Synonyms: Methylselenocysteine; Se-Methylseleno-L-cysteine)

Se-Methylselenocysteine，甲基硒的前体，具有强大的癌症化学预防活性和抗氧化活性。Se-Methylselenocysteine 具有口服生物活性，可诱导细胞凋亡 (apoptosis)。

Se-Methylselenocysteine(Synonyms: Methylselenocysteine; Se-Methylseleno-L-cysteine)

Se-Methylselenocysteine Chemical Structure

CAS No. : 26046-90-2

规格 价格 是否有货 数量
10 mM * 1 mL in Water ￥550 In-stock
5 mg ￥500 In-stock
10 mg ￥850 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Se-Methylselenocysteine 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus
  • Apoptosis Compound Library
  • Metabolism/Protease Compound Library
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Clinical Compound Library
  • Anti-Aging Compound Library
  • Oxygen Sensing Compound Library
  • Orally Active Compound Library
  • Traditional Chinese Medicine Monomer Library
  • Anti-Alzheimer’s Disease Compound Library
  • Food-Sourced Compound Library

生物活性

Se-Methylselenocysteine, a precursor of Methylselenol, has potent cancer chemopreventive activity and anti-oxidant activity. Se-Methylselenocysteine is orally bioavailable, and induces apoptosis[1][2].

体外研究
(In Vitro)

Se-Methylselenocysteine (100-400 μM; 3 days) induces apoptosis in SKOV-33 cells[1].
Se-Methylselenocysteine (100-400 μM; 3 days) induces caspase-3 mediated apoptosis[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: SKOV-3 cells
Concentration: 100, 200, 400 μM
Incubation Time: 3 days
Result: Resulted in a markedly increased accumulation of Sub-G1 phase, which occurred in both SeMSC concentration and culture time-dependent.

Western Blot Analysis[1]

Cell Line: SKOV-3 cells
Concentration: 100, 200, 400 μM
Incubation Time: 3 days
Result: Resulted in a decrease in the expression of the 32 kDa form of procaspase-3.

体内研究
(In Vivo)

Se-Methylselenocysteine (0.2 mg/mouse; p.o.; daily for 14 days) potentiates the antitumour activity of CDDP and Cyclophosphamide in nude mice bearing human FaDu and A253 head and neck xenografts[2].
Alzheimer’s disease (AD) mice are treats with Se-Methylselenocysteine (0.75 mg/kg BW per day) in their drinking water for 10 months. Se-Methylselenocysteine reduces oxidative stress and neuro-inflammation; Se-Methylselenocysteine modulates the distribution and levels of several metal ions; Se-Methylselenocysteine decreases amyloid-β peptide (Aβ) generation by inhibiting the expression of its precursor protein APP and β-secretase (BACE1), and attenuates tau hyperphosphorylation and neurofibrillary tangles (NFT) formation via promoting protein phosphatase 2A (PP2A) activity, thereby preserving synaptic proteins and neuron activities and finally improving spatial learning and memory deficits in AD model mice[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female athymic nude mice (bearing human A253 and FaDu squamous cell carcinoma xenografts)[2]
Dosage: 0.2 mg/mouse
Administration: p.o.; daily for 14 days (7 days before and 7 days after Cyclophosphamide or CDDP in a total of 14 days)
Result:

Clinical Trial

分子量

182.08

Formula

C4H9NO2Se
CAS 号

26046-90-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

H2O : 83.33 mg/mL (457.66 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 5.4921 mL 27.4605 mL 54.9209 mL
5 mM 1.0984 mL 5.4921 mL 10.9842 mL
10 mM 0.5492 mL 2.7460 mL 5.4921 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Yeo JK, et al. Se-methylselenocysteine induces apoptosis through caspase activation and Bax cleavage mediated by calpain in SKOV-3 ovarian cancer cells. Cancer Lett. 2002 Aug 8;182(1):83-92.

    [2]. Cao S, et al. Se-methylselenocysteine offers selective protection against toxicity and potentiates the antitumour activity of anticancer drugs in preclinical animal models. Br J Cancer. 2014 Apr 2;110(7):1733-43.

    [3]. Xie Y, et al. Se-Methylselenocysteine Ameliorates Neuropathology and Cognitive Deficits by Attenuating Oxidative Stress and Metal Dyshomeostasis in Alzheimer Model Mice. Mol Nutr Food Res. 2018 Jun;62(12):e1800107.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

发表回复