Thalidomide-O-amido-PEG2-C2-NH2 TFA(Synonyms: Cereblon Ligand-Linker Conjugates 10 TFA; E3 Ligase Ligand-Linker Conjugates 24 TFA)

发表于由

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Thalidomide-O-amido-PEG2-C2-NH2 TFA (Synonyms: Cereblon Ligand-Linker Conjugates 10 TFA; E3 Ligase Ligand-Linker Conjugates 24 TFA) 纯度: 99.52%

Thalidomide-O-amido-PEG2-C2-NH2 TFA 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 Thalidomide 的 cereblon 配体和 2 个单元的 PEG linker。

Thalidomide-O-amido-PEG2-C2-NH2 TFA(Synonyms: Cereblon Ligand-Linker Conjugates 10 TFA; E3 Ligase Ligand-Linker Conjugates 24 TFA)

Thalidomide-O-amido-PEG2-C2-NH2 TFA Chemical Structure

CAS No. : 1957235-75-4

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
100 mg ￥3500 In-stock
500 mg ￥13500 In-stock
1 g ￥25000 In-stock
2 g ￥35000 In-stock
5 g   询价  
10 g   询价  

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生物活性

Thalidomide-O-amido-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology.

IC50 & Target

Cereblon

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

576.48

Formula

C23H27F3N4O10
CAS 号

1957235-75-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro: 

H2O : 150 mg/mL (260.20 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7347 mL 8.6733 mL 17.3467 mL
5 mM 0.3469 mL 1.7347 mL 3.4693 mL
10 mM 0.1735 mL 0.8673 mL 1.7347 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. ARYL SULFONOHYDRAZIDES. WO 2017/176958 A1.

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