NSC745885

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

NSC745885  纯度: ≥98.0%

NSC745885 是一种有效的抗肿瘤 (anti-tumor) 试剂,对多种癌细胞株有选择性毒性,但对正常细胞没有毒性。NSC745885 是一种有效的 EZH2 的下调因子通过蛋白酶体降解途径。NSC745885 为晚期膀胱癌和口腔鳞癌的研究提供了可能性。

NSC745885

NSC745885 Chemical Structure

CAS No. : 4219-52-7

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
5 mg ¥2500 In-stock
10 mg ¥4500 In-stock
50 mg ¥13000 In-stock
100 mg ¥18000 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

NSC745885 相关产品

相关化合物库:

  • Bioactive Compound Library Plus

生物活性

NSC745885 an effective anti-tumor agent, shows selective toxicity against multiple cancer cell lines but not normal cells. NSC745885 is an effective down-regulator of EZH2 via proteasome-mediated degradation. NSC745885 provides possibilities for the study of advanced bladder and oral squamous cell carcinoma (OSCC) cancers[1][2].

IC50 & Target[2]

EZH2

 

体外研究
(In Vitro)

NSC745885 (0.5-4 μM; 24, 48 or 72 hours) has a growth inhibitory or death-promoting effect on the SAS cells, it significantly decreases the densities of cultured cells when compared with untreated cells. The IC50 of NSC745885 is 0.85 μM after 72 hours’ treatment[1].
NSC745885 (0.5-4 μM; 24 hours) increases annexin V positive cells in a dose-dependent manner, and the differences appears as a dose-dependent manner[1].
NSC745885 (0.5-2 μM; 24 or 48 hours) decreases XIAP protein levels and increases protein levels both as a dose-dependent manner in SAS cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: SAS cells is obtained from a poorly differentiated human squamous cell carcinoma
Concentration: 0.5 μM, 1 μM, 1.5 μM, 2 μM, 4 μM
Incubation Time: 24, 48, or 72 hours
Result: Decreases SAS cells growth as a time and dose-dependent manner.

Apoptosis Analysis[1]

Cell Line: SAS cells is obtained from a poorly differentiated human squamous cell carcinoma
Concentration: 0.5 μM, 1 μM, 1.5 μM, 2 μM, 4 μM
Incubation Time: 24 hours
Result: Decreases SAS cells growth as a time and dose-dependent manner.

Western Blot Analysis[1]

Cell Line: SAS cells is obtained from a poorly differentiated human squamous cell carcinoma
Concentration: 0.5 μM, 1 μM, 1.5 μM, 2 μM
Incubation Time: 24 or 48 hours
Result: Increased cleaved caspase-3 expression and decreased XIAP expression.

体内研究
(In Vivo)

NSC745885 (intraperitoneal injection; 2 mg/kg; once daily; 10 days) treatment significantly reduces tumor size when compared with the vehicle control, and exhibits a higher safety than doxorubicin[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight-week-old NOD/SCID (NOD.CB17 Prkdcscid/J) mice[1]
Dosage: 2 mg/kg
Administration: Intraperitoneal injection; 2 mg/kg; once daily; 10 days
Result: Inhibited engrafted tumors growth in vivo.

分子量

266.27

Formula

C14H6N2O2S

CAS 号

4219-52-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : < 1 mg/mL (insoluble or slightly soluble)

*NSC745885 is usually formulated as a suspension.

参考文献
  • [1]. Chen YW, et al.A novel compound NSC745885 exerts an anti-tumor effect on tongue cancer SAS cells in vitro and in vivo.PLoS One. 2014 Aug 15;9(8):e104703.

    [2]. Tang SH, et al. Pharmacologic down-regulation of EZH2 suppresses bladder cancer in vitro and in vivo.Oncotarget. 2014 Nov 15;5(21):10342-55.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务