Nanaomycin A

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Nanaomycin A 

Nanaomycin A 是第一个选择性 DNMT3B 抑制剂，IC50 为 500 nM。Nanaomycin A 是一种醌类抗生素，可重新激活人类癌细胞中沉默的抑癌基因。Nanaomycin A 抑制人疟原虫恶性疟原虫的体外生长，IC80 值为 33.1 nM。

Nanaomycin A

Nanaomycin A Chemical Structure

CAS No. : 52934-83-5

规格 价格 是否有货
5 mg ￥10500 询问价格 & 货期
10 mg ￥18000 询问价格 & 货期
25 mg ￥29500 询问价格 & 货期

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生物活性

Nanaomycin A is the first selective DNMT3B inhibitor with an IC50 of 500 nM. Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells[1]. Nanaomycin A inhibits in vitro growth of the human malaria parasite Plasmodium falciparum with an IC80 value of 33.1 nM[2].

IC50 & Target[1]

DNMT3B

500 nM (IC50)

体外研究
(In Vitro)

Nanaomycin A (10-10000 nM; 72 hours) has a distinct cytotoxic effect in all three cell lines[1].
Nanaomycin A (0.5, 5 μM; 72 hours) reveals induction of RASSF1A protein expression in A549 cells[1].
Nanaomycin A (5 μM; 72 hours) has an 18-fold relative induction[1].
Nanaomycin A not affects the enzymatic activity of DNMT1[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: HCT116 (colon), A549 (lung), and HL60 (bone marrow) human tumor cell lines
Concentration: 10, 100, 1000, 10000 nM
Incubation Time: 72 hours
Result: Had a distinct cytotoxic effect in all three cell lines.

Western Blot Analysis[1]

Cell Line: A549 cells
Concentration: 0.5, 5 μM
Incubation Time: 72 hours
Result: Revealed induction of RASSF1A protein expression.

RT-PCR[1]

Cell Line: A549 cells
Concentration: 5 μM
Incubation Time: 72 hours
Result: Had an 18-fold relative induction.

分子量

302.28

Formula

C16H14O6
CAS 号

52934-83-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Kuck D, et al.Nanaomycin A selectively inhibits DNMT3B and reactivates silenced tumor suppressor genes in human cancer cells.Mol Cancer Ther. 2010 Nov;9(11):3015-23.

    [2]. Tanaka Y, et al.Heme-dependent radical generation: possible involvement in antimalarial action of non-peroxide microbial metabolites, nanaomycin A and radicicol.J Antibiot (Tokyo). 1999 Oct;52(10):880-8.

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