Hexylresorcinol(Synonyms: 4-己基间苯二酚; 4-Hexylresorcinol)

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Hexylresorcinol (Synonyms: 4-己基间苯二酚; 4-Hexylresorcinol) 纯度: 98.29%

Hexylresorcinol (4-Hexylresorcinol) 是在植物中发现的一种天然化合物，具有抗菌、驱虫、防腐和抗肿瘤活性。Hexylresorcinol 可诱导鳞癌细胞凋亡 (apoptosis)。Hexylresorcinol 是一种可逆、非竞争性的 α-葡萄糖苷酶 (α-glucosidase) 抑制剂。Hexylresorcinol 具有抗 DNA 氧化损伤的保护作用。

Hexylresorcinol(Synonyms: 4-己基间苯二酚; 4-Hexylresorcinol)

Hexylresorcinol Chemical Structure

CAS No. : 136-77-6

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10 mM * 1 mL in DMSO ￥500 In-stock
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生物活性

Hexylresorcinol (4-Hexylresorcinol) is a natural compound found in plants with antimicrobial, anthelmintic, antiseptic and antitumor activities. Hexylresorcinol can induce apoptosis in squamous carcinoma cells. Hexylresorcinol is a reversible and noncompetitive inhibitor of α-glucosidase. Hexylresorcinol has protective effects against oxidative DNA damage[1][2][3][4][5].

IC50 & Target

α-glucosidase[4]
体外研究
(In Vitro)

Hexylresorcinol potently inhibits Gram positive bacteria, with MICs of 20-50 mg/L for several Gram positive bacteria. Gram negative bacteria, yeasts and fungi are less sensitive to it[1].
Hexylresorcinol inhibits oxidative DNA damage in human lymphocytes by increasing levels of glutathione and modulation of antioxidant enzymes (GPX, GR and GST)[2].
Hexylresorcinol (1-10 µg/mL; 24-72 hours) suppresses squamous carcinoma cell line SCC-9 proliferation[3].
Hexylresorcinol has strong antitumor effects by inhibiting calcium channel oscillation and inducing apoptosis[3].
Hexylresorcinol upregulates TGF-β/SMAD/VEGF signaling in endothelial cells and induces vascular regeneration and remodeling for wound healing[5].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[3]

Cell Line: SCC-9 cells
Concentration: 1 µg/mL, 5 µg/mL, 10 µg/mL
Incubation Time: 24 hours, 48 hours, 72 hours
Result: Inhibited SCC-9 cells proliferation.

Apoptosis Analysis[3]

Cell Line: SCC-9 cells
Concentration: 10 µg/mL
Incubation Time: 24 hours
Result: Induced morphological and biochemical changes in SCC-9 cells.

体内研究
(In Vivo)

Hexylresorcinol (10 mg/kg; i.p.; daily; for 16 days) inhibits tumor cell proliferation in mouse tumor xenografts and concomitant application of calcium channel blocker partly reverses the antitumor effect of Hexylresorcinol[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male nude mice (BALB/cAnNCrj-nu/nu), with SCC-9 cells xenograft[3]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection, daily, for 16 days
Result: Reduced tumor formation in vivo.

分子量

194.27

Formula

C12H18O2
CAS 号

136-77-6
中文名称

己雷琐辛；4-己基间苯二酚
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 250 mg/mL (1286.87 mM; Need ultrasonic)

Ethanol : 100 mg/mL (514.75 mM; Need ultrasonic)

H2O : 1 mg/mL (5.15 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 5.1475 mL 25.7374 mL 51.4748 mL
5 mM 1.0295 mL 5.1475 mL 10.2950 mL
10 mM 0.5147 mL 2.5737 mL 5.1475 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% EtOH    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (12.87 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (12.87 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 EtOH 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% EtOH    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (12.87 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (12.87 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 EtOH 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% EtOH    90% corn oil

    Solubility: ≥ 2.5 mg/mL (12.87 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (12.87 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 EtOH 储备液加到 900 μL玉米油中，混合均匀。

  • 4.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (10.71 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (10.71 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 5.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (10.71 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (10.71 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 6.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (10.71 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (10.71 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献

  • [1]. Y. A. Nikolaev, et al. The use of 4-Hexylresorcinol as antibiotic adjuvant. PLoS One. 2020; 15(9): e0239147.

    [2]. Gow-Chin Yen, et al. Effects of resveratrol and 4-hexylresorcinol on hydrogen peroxide-induced oxidative DNA damage in human lymphocyte. Free Radic Res. 2003 May;37(5):509-14.

    [3]. Seong-Gon Kim, et al. 4-hexylresorcinol exerts antitumor effects via suppression of calcium oscillation and its antitumor effects are inhibited by calcium channel blockers. Oncol Rep. 2013 May;29(5):1835-40.

    [4]. Shuang Song, et al. Inhibitory potential of 4-hexylresorcinol against α-glucosidase and non-enzymatic glycation: Activity and mechanism. J Biosci Bioeng. 2020 Nov 12;S1389-1723(20)30400-X.

    [5]. Min-Keun Kim, et al. 4-Hexylresorcinol induced angiogenesis potential in human endothelial cells. Maxillofac Plast Reconstr Surg. 2020 Dec; 42(1): 23.

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