上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
CAY10404 纯度: 99.79%
CAY10404 是一种有效且高度选择性的环氧合酶 2 (COX-2) 抑制剂,IC50 为 1 nM,选择性指数 (SI;COX-1 IC50/COX-2 IC50) 为 >500000。CAY10404 是有效的 PKB/Akt 和 MAPK 信号通路抑制剂,可诱导非小细胞肺癌 (NSCLC) 细胞凋亡 (apoptosis)。CAY10404 是一种二芳基异恶唑,具有良好的止痛,抗炎和抗癌活性。
CAY10404 Chemical Structure
CAS No. : 340267-36-9
规格 | 价格 | 是否有货 | 数量 |
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Free Sample (0.1-0.5 mg) | Apply now | ||
10 mM * 1 mL in DMSO | ¥1100 | In-stock | |
5 mg | ¥1000 | In-stock | |
10 mg | ¥1800 | In-stock | |
25 mg | ¥3800 | In-stock | |
50 mg | ¥6500 | In-stock | |
100 mg | ¥10500 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
* Please select Quantity before adding items.
CAY10404 相关产品
•相关化合物库:
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生物活性 |
CAY10404 is a potent and selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 1 nM and a selectivity index (SI; COX-1 IC50/COX-2 IC50) of >500000. CAY10404 is a potent PKB/Akt and MAPK signaling pathways inhibitor and induces apoptosis in non-small cell lung cancer (NSCLC) cells. CAY10404, a diarylisoxazole, has good analgesic, anti-inflammatory, and anti-cancer activities[1][2][3]. |
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IC50 & Target |
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体外研究 (In Vitro) |
CAY10404 (compound 7) exhibits no inhibition of COX-1 (IC50>500 µM)[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[3]
Apoptosis Analysis[3]
Western Blot Analysis[3]
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体内研究 (In Vivo) |
CAY10404 (50 mg/kg/day; ip; for 4 days) decreases lung inflammation in HTV mice and attenuates ventilator-induced lung injury[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
367.34 |
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Formula |
C17H12F3NO3S |
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CAS 号 |
340267-36-9 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
-20°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) |
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溶解性数据 |
In Vitro:
DMSO : 100 mg/mL (272.23 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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