N-Bis(2-hydroxypropyl)nitrosamine(Synonyms: DHPN; Di(2-hydroxypropyl)nitrosamine; Diisopropanolnitrosamine)

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N-Bis(2-hydroxypropyl)nitrosamine (Synonyms: DHPN; Di(2-hydroxypropyl)nitrosamine; Diisopropanolnitrosamine) 纯度: ≥98.0%

N-Bis(2-hydroxypropyl)nitrosamine 是一种具有致癌作用的试剂。

N-Bis(2-hydroxypropyl)nitrosamine(Synonyms: DHPN; Di(2-hydroxypropyl)nitrosamine; Diisopropanolnitrosamine)

N-Bis(2-hydroxypropyl)nitrosamine Chemical Structure

CAS No. : 53609-64-6

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ￥660 In-stock
10 mg ￥600 In-stock
25 mg ￥1200 In-stock
50 mg ￥1900 In-stock
100 mg ￥2900 In-stock
200 mg ￥4900 In-stock
500 mg   询价  
1 g   询价  

* Please select Quantity before adding items.

N-Bis(2-hydroxypropyl)nitrosamine 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Anti-Cancer Compound Library

生物活性

N-Bis(2-hydroxypropyl)nitrosamine is an agent with carcinogenic activity.

体外研究
(In Vitro)

N-Bis(2-hydroxypropyl)nitrosamine is an agent with carcinogenic activity[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

N-Bis(2-hydroxypropyl)nitrosamine causes the tumors to develop in the lung, liver, and thyroid of rats at a dose of 100 ppm, in the lung, liver thyroid, esophagus, kidney, and urinary bladder of rats at a dose of 500 ppm, and in the lung, liver thyroid, esophagus, kidney, and urinary bladder of rats at both doses[1]. Bisphenol A (BPA) enhances the susceptibility to thyroid carcinoma stimulated by N-Bis(2-hydroxypropyl)nitrosamine (DHPN; 2800 mg/kg) in rats[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

162.19

Formula

C6H14N2O3
CAS 号

53609-64-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : ≥ 125 mg/mL (770.70 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 6.1656 mL 30.8280 mL 61.6561 mL
5 mM 1.2331 mL 6.1656 mL 12.3312 mL
10 mM 0.6166 mL 3.0828 mL 6.1656 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Konishi Y, et al. Effect of dose on the carcinogenic activity of orally administered N-bis(2-hydroxypropyl)nitrosamine in rats. Gan. 1978 Aug;69(4):573-7.

    [2]. Zhang J, et al. Low dose of Bisphenol A enhance the susceptibility of thyroid carcinoma stimulated by DHPN and iodine excess in F344 rats. Oncotarget. 2017 Jul 22;8(41):69874-69887.

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