SJF620 hydrochloride

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

SJF620 hydrochloride  纯度: 99.28%

SJF620 hydrochloride 是一种由Cereblon配体和Btk配体相连的PROTAC，DC50 为 7.9 nM。SJF620 含有 Lenalidomide 类似物，可募集 CRBN。

SJF620 hydrochloride

SJF620 hydrochloride Chemical Structure

规格 价格 是否有货
5 mg ￥5800 询问价格 & 货期
10 mg ￥9800 询问价格 & 货期
25 mg ￥19000 询问价格 & 货期

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SJF620 hydrochloride 的其他形式现货产品:

SJF620

生物活性

SJF620 hydrochloride is a PROTAC connected by ligands for Cereblon and Btk with a DC50 of 7.9 nM. SJF620 contains a Lenalidomide analog for recruiting CRBN[1].

IC50 & Target[1]

Cereblon

 

体外研究
(In Vitro)

SJF620 hydrochloride is a PROTAC that retains potent degradation of BTK in cellular assays with a DC50 of 7.9 nM in Burkitt lymphoma cell line NAMALWA[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

SJF620 hydrochloride has a super pharmacokinetic profile in mice (1 mg/kg; i.v.) with the half life (t1/2) of 1.64 h. SJF620 exhibits a significantly better pharmacokinetic profile than MT802[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

797.30

Formula

C41H45ClN8O7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
参考文献

  • [1]. Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30(3):126877.

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