sulfo-SPDB-DM4

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

sulfo-SPDB-DM4 

sulfo-SPDB-DM4 是 ADC 的一部分,由 maytansinebased payload (DM4,一种微管抑制剂) 与 sulfo-SPDB 连接而成。

sulfo-SPDB-DM4

sulfo-SPDB-DM4 Chemical Structure

CAS No. : 1626359-59-8

规格 价格 是否有货
1 mg ¥17000 询问价格 & 货期
5 mg ¥51000 询问价格 & 货期
10 mg ¥86000 询问价格 & 货期
25 mg ¥160000 询问价格 & 货期
50 mg ¥250000 询问价格 & 货期

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生物活性

sulfo-SPDB-DM4 is a drug-linker conjugate for ADC by using the maytansinebased payload (DM4, an antitubulin agent) via the sulfo-SPDB linker.

IC50 & Target

Maytansinoids

 

体外研究
(In Vitro)

DM4, a structural analogue of maytansine, is a new thiol-containing and potent maytansinoid. DM4 is a cytotoxic maytansinoid drug. It is synthesized in order to link maytansinoids to antibodies via disulfide bonds. Maytansinoids inhibit tubulin polymerization and microtubule assembly and enhance microtubule destabilization, so there is potent suppression of microtubule dynamics resulting in a mitotic block and subsequent apoptotic cell death[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1075.66

Formula

C46H63ClN4O17S3

CAS 号

1626359-59-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
参考文献
  • [1]. Tang R, et al. P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients. BMC Cancer. 2009 Jun 23;9:199.

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