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(S,R,S)-AHPC-C6-PEG3-C4-Cl (Synonyms: VH032-C6-PEG3-C4-Cl; VHL Ligand-Linker Conjugates 12; E3 ligase Ligand-Linker Conjugates 8) 纯度: 95.46%
(S,R,S)-AHPC-C6-PEG3-C4-Cl 由 E3 配体与 20 个原子相连的复合分子,连接子的接头为 Halogen 基团。(S,R,S)-AHPC-C6-PEG3-C4-Cl 包含基于 (S,R,S)-AHPC 的 VHL 配体和 基于一个 alkyl/ether linker。(S,R,S)-AHPC-C6-PEG3-C4-Cl 能够诱导 GFP-HaloTag7 降解。
(S,R,S)-AHPC-C6-PEG3-C4-Cl Chemical Structure
CAS No. : 1835705-55-9
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100 mg | ¥3500 | In-stock | |
500 mg | ¥13500 | In-stock | |
1 g | ¥25000 | In-stock | |
2 g | ¥35000 | In-stock | |
5 g | 询价 | ||
10 g | 询价 |
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生物活性 |
(S,R,S)-AHPC-C6-PEG3-C4-Cl (VH032-C6-PEG3-C4-Cl) is a conjugate of ligands for E3 and 20-atom-length linker. The connector of linker is Halogen group. (S,R,S)-AHPC-C6-PEG3-C4-Cl incorporates the (S,R,S)-AHPC based VHL ligand and an alkyl/ether-based linker. (S,R,S)-AHPC-C6-PEG3-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1]. |
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IC50 & Target[1] |
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体外研究 (In Vitro) |
(S,R,S)-AHPC-C6-PEG3-C4-Cl uses the cereblon ligand[1]. The linker is 6-2-2-6. The linkers contain a mixture of hydrophobic and hydrophilic moieties to balance the hydrophobicity/hydrophilicity of the resulting hybrid compounds. PROTACs that induce the degradation of an oncogenic tyrosine kinase, BCR-ABL has been developed. (S,R,S)-AHPC-C6-PEG3-C4-Cl can be attached to potent TKIs (bosutinib and dasatinib) that mediate the degradation of c-ABL and BCR-ABL by hijacking either CRBN or VHL E3 ubiquitin ligase [2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
751.42 |
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Formula |
C38H59ClN4O7S |
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CAS 号 |
1835705-55-9 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
Ethanol : 100 mg/mL (133.08 mM; Need ultrasonic) DMSO : ≥ 100 mg/mL (133.08 mM) * “≥” means soluble, but saturation unknown. 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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