Lin28-let-7a antagonist 1

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Lin28-let-7a antagonist 1  纯度: 99.62%

Lin28-let-7a antagonist 1 对 Lin28-let-7a 的结合有明显的拮抗作用,其对 Lin28A-let-7a-1 结合的 IC50 值为 4.03 μM。

Lin28-let-7a antagonist 1

Lin28-let-7a antagonist 1 Chemical Structure

CAS No. : 2024548-03-4

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥4750 In-stock
5 mg ¥3700 In-stock
10 mg ¥6500 In-stock
50 mg ¥18600 In-stock
100 mg   询价  
200 mg   询价  

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生物活性

Lin28-let-7a antagonist 1 shows a clear antagonistic effect against the Lin28-let-7a interaction with an IC50 of 4.03 μM for Lin28A-let-7a-1 interaction.

IC50 & Target

IC50:4.03 μM (Lin28A-let-7a-1)[1].

体外研究
(In Vitro)

Lin28-let-7a antagonist 1 (compound 1) shows a clear antagonistic effect against the Lin28A-let-7a-1 interaction with an IC50 of 4.03 μM. Interestingly, Lin28-let-7a antagonist 1 also inhibits the Lin28B-let-7 interaction, with slightly reduced potency. Dicer processing assay reveals that Lin28-let-7a antagonist 1 clearly blocks the formation of the Lin28A-pre-let-7g complex and induces miRNA processing, resulting in the generation of mature let-7g miRNA. When the expression of both Lin28A and Lin28B are knocked-down using siRNA in JAR cells, the Lin28-let-7a antagonist 1-induced increase in cellular let-7 levels is clearly attenuated. Lin28A-let-7a-IN-1 increases mature let-7 levels in PA-1 cells that express high level of Lin28A. On the other hand, let-7 levels are not affected by 1 in MCF7 cells that rarely express Lin28 proteins. Taken together, Lin28-let-7a antagonist 1 specifically induces the increase in the cellular let-7 levels by targeting Lin28[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

583.59

Formula

C31H29N5O7

CAS 号

2024548-03-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (171.35 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7135 mL 8.5677 mL 17.1353 mL
5 mM 0.3427 mL 1.7135 mL 3.4271 mL
10 mM 0.1714 mL 0.8568 mL 1.7135 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Lim D, et al. Discovery of a Small-Molecule Inhibitor of Protein-MicroRNA Interaction Using Binding Assay with a Site-Specifically Labeled Lin28. J Am Chem Soc. 2016 Oct 7.

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