TCS JNK 5a(Synonyms: JNK Inhibitor IX)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

TCS JNK 5a (Synonyms: JNK Inhibitor IX) 纯度: 98.06%

TCS JNK 5a 是一种有效的 JNK3 抑制剂，pIC50 为 6.7。TCS JNK 5a 也抑制 JNK2，pIC50为 6.5。

TCS JNK 5a(Synonyms: JNK Inhibitor IX)

TCS JNK 5a Chemical Structure

CAS No. : 312917-14-9

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥550 In-stock
5 mg ￥500 In-stock
10 mg ￥900 In-stock
50 mg ￥2500 In-stock
100 mg ￥4500 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

TCS JNK 5a 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Apoptosis Compound Library
  • Immunology/Inflammation Compound Library
  • Kinase Inhibitor Library
  • MAPK Compound Library
  • Anti-Cancer Compound Library
  • Reprogramming Compound Library
  • Oxygen Sensing Compound Library
  • Anti-Parkinson’s Disease Compound Library
  • Anti-Obesity Compound Library
  • Transcription Factor Targeted Library

生物活性

TCS JNK 5a is a potent JNK3 inhibitor with a pIC50 of 6.7. TCS JNK 5a also inhibits JNK2 with a pIC50 of 6.5.

IC50 & Target[1]

JNK3

6.7 (pIC50)

JNK2

6.5 (pIC50)

体外研究
(In Vitro)

TCS JNK 5a is also screened in a panel of more than 30 kinase assays, including Alk5, c-Fms, CDK-2, EGFR, ErbB2, GSK3β, PLK1, Src, Tie-2 and VegFr2, and is inactive (pIC50<5.0) against all of them[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

332.42

Formula

C20H16N2OS
CAS 号

312917-14-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : ≥ 51 mg/mL (153.42 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.0082 mL 15.0412 mL 30.0824 mL
5 mM 0.6016 mL 3.0082 mL 6.0165 mL
10 mM 0.3008 mL 1.5041 mL 3.0082 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Angell RM, et al. N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1296-301.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务