BMS453(Synonyms: BMS-189453)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

BMS453 (Synonyms: BMS-189453) 纯度: 98.89%

BMS453 (BMS-189453) 是一种合成类维生素 A，是一种 RARβ 激动剂和 RARα/RARγ 拮抗剂。BMS453 主要通过诱导活性 TGFβ 来抑制乳腺细胞生长。

BMS453(Synonyms: BMS-189453)

BMS453 Chemical Structure

CAS No. : 166977-43-1

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生物活性

BMS453 (BMS-189453), a synthetic retinoid, is a RARβ agonist and a RARα/RARγ antagonist. BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ[1][2].

体外研究
(In Vitro)

BMS453 (1 μM; 11 hours; 184 and HMEC cells) treatment inhibits the proliferation of normal breast cell growth without significantly inducing apoptosis[2].
BMS453 (1 μM; 5 days; 184 and HMEC cells) treatment inhibits normal breast cell proliferation by causing G1 arrest[2].
BMS453 (1 μM; 24-72 hours; 184 cells) treatment induces Rb hypophosphorylation and decrease CDK2 kinase activity. BMS453 increases total p21 protein levels and CDK2-bound p21 protein, but does not change CDK4-bound p21[2].
BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: Normal human mammary epithelial cells (184 and HMEC)
Concentration: 1 μM
Incubation Time: 11 hours
Result: Inhibited 3H-thymidine uptake in normal breast cells (184 and HMEC) by 40 %.

Cell Cycle Analysis[2]

Cell Line: Normal human mammary epithelial cells (184 and HMEC)
Concentration: 1 μM
Incubation Time: 5 days
Result: Increased the proportion of cells in G0/G1 phase and decreased the proportion of cells in S phase.

Western Blot Analysis[2]

Cell Line: 184 cells
Concentration: 1 μM
Incubation Time: 24 hours, 48 hours, 72 hours
Result: Induced Rb hypophosphorylation and decrease CDK2 kinase activity.

分子量

380.48

Formula

C27H24O2
CAS 号

166977-43-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
参考文献

  • [1]. J Y Chen, et al. RAR-specific agonist/antagonists which dissociate transactivation and AP1 transrepression inhibit anchorage-independent cell proliferation. EMBO J. 1995 Mar 15;14(6):1187-97.

    [2]. L Yang, et al. The retinoic acid receptor antagonist, BMS453, inhibits normal breast cell growth by inducing active TGFbeta and causing cell cycle arrest. Oncogene. 2001 Nov 29;20(55):8025-35.

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