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Peldesine dihydrochloride (Synonyms: BCX 34 dihydrochloride) 纯度: 99.80%
Peldesine (BCX 34) dihydrochloride 是一种有效的,竞争性,可逆和口服活性的嘌呤核苷磷酸化酶 (PNP) 抑制剂,对人,大鼠和小鼠红细胞 (RBC) PNP 的 IC50 分别为 36 nM,5 nM 和 32 nM。Peldesine dihydrochloride 还是一种 T 细胞 (T-cell) 增殖抑制剂,IC50 为 800 nM。Peldesine dihydrochloride 可用于皮肤 T 细胞淋巴瘤,牛皮癣和 HIV 感染的研究。
Peldesine dihydrochloride Chemical Structure
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥4620 | In-stock | |
5 mg | ¥4200 | In-stock | |
10 mg | ¥7000 | In-stock | |
50 mg | 询价 | ||
100 mg | 询价 |
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Peldesine dihydrochloride 相关产品
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生物活性 |
Peldesine (BCX 34) dihydrochloride is a potent, competitive, reversible and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50s of 36 nM, 5 nM, and 32 nM for human, rat, and mouse red blood cell (RBC) PNP, respectively. Peldesine dihydrochloride is also a T-cell proliferation inhibitor with an IC50 of 800 nM. Peldesine dihydrochloride has the potential for cutaneous T-cell lymphoma, psoriasis and HIV infection research[1][2][3][4]. |
IC50 & Target |
IC50: 36 nM (Human RBC PNP), 5 nM (Rat RBC PNP), 32 nM (Mouse RBC PNP), and 800 nM (Human T-cell proliferation)[3] |
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体外研究 (In Vitro) |
Peldesine (BCX 34; 0-50 µM; 72 hours; Jurkat cells) could inhibit the T-cell proliferation completely at a concentration of less than 10 μM, in the presence of dGuo (10 μM). In contrast, the B-cell proliferation is not affected by Peldesine[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[1]
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Clinical Trial |
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分子量 |
314.17 |
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Formula |
C12H13Cl2N5O |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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溶解性数据 |
In Vitro:
DMSO : 200 mg/mL (636.60 mM; Need ultrasonic) H2O : 33.33 mg/mL (106.09 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
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参考文献 |
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