DOTATATE acetate

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DOTATATE acetate  纯度: 98.85%

DOTATATE acetate 是一种 DOTA 偶联肽，可以被放射性核素标记以用于正电子发射断层扫描 (PET) 成像和肽受体放射性核素治疗 (PRRT)。

DOTATATE acetate

DOTATATE acetate Chemical Structure

CAS No. : 177943-89-4

规格 价格 是否有货 数量
5 mg ￥2500 In-stock
10 mg ￥4200 In-stock
25 mg ￥7500 In-stock
50 mg   询价  
100 mg   询价  

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DOTATATE acetate 相关产品

•相关化合物库:

  • Drug Repurposing Compound Library Plus
  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus
  • Macrocyclic Compound Library

生物活性

DOTATATE acetate is a DOTA-conjugated peptide. DOTATATE acetate can be labelled with radionuclides for positron emission tomography (PET) imaging and peptide receptor radionuclide therapy (PRRT)[1][2][3][4].

体内研究
(In Vivo)

177Lu-DOTATATE shows excellent antitumor effects in rats[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

Formula

C65H90N14O19S2.xC2H4O2
CAS 号

177943-89-4
Sequence Shortening

{D-Phe}-CY-{D-Trp}-KTCT (Disulfide bridge:Cys2-Cys7)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Protect from light, stored under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
溶解性数据
In Vitro: 

H2O : 8.33 mg/mL (ultrasonic and warming and heat to 60°C)
参考文献

  • [1]. Jong M, et, al. Combination radionuclide therapy using 177Lu- and 90Y-labeled somatostatin analogs. J Nucl Med. 2005 Jan;46 Suppl 1:13S-7S.

    [2]. Gains JE, et, al. 68Ga-DOTATATE and 123I-mIBG as imaging biomarkers of disease localisation in metastatic neuroblastoma: implications for molecular radiotherapy. Nucl Med Commun. 2020 Aug 10.

    [3]. Breeman WAP, et, al. Optimising conditions for radiolabelling of DOTA-peptides with 90Y, 111In and 177Lu at high specific activities. Eur J Nucl Med Mol Imaging. 2003 Jun;30(6):917-20.

    [4]. Reubi JC, et, al. Affinity profiles for human somatostatin receptor subtypes SST1-SST5 of somatostatin radiotracers selected for scintigraphic and radiotherapeutic use. Eur J Nucl Med. 2000 Mar;27(3):273-82.

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