上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
VZ185 纯度: 98.34%
VZ185 是高效,快速,选择性的基于von Hippel-Lindau的BRD9和BRD7双降解探针,DC50 分别为 4.5 和 1.8 nM。VZ185对 EOL-1 和 A-402 细胞具有细胞毒性,EC50 分别为 3nM 和 40nM。
VZ185 Chemical Structure
CAS No. : 2306193-61-1
规格 | 价格 | 是否有货 | 数量 |
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5 mg | ¥2500 | In-stock | |
10 mg | ¥4200 | In-stock | |
25 mg | ¥8900 | In-stock | |
50 mg | ¥15000 | In-stock | |
100 mg | 询价 | ||
200 mg | 询价 |
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VZ185 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Epigenetics Compound Library
- Histone Modification Research Compound Library
- Anti-Cancer Compound Library
- Reprogramming Compound Library
- Chemical Probe Library
- Anti-Blood Cancer Compound Library
- Targeted Diversity Library
生物活性 |
VZ185 is a potent, fast, and selective von Hippel-Lindau based dual degrader probe of BRD9 and BRD7 with DC50s of 4.5 and 1.8 nM, respectively. VZ185 is cytotoxic in EOL-1 and A-402 cells, with EC50s of 3 nM and 40 nM, respectively[1]. |
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IC50 & Target[1] |
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体外研究 (In Vitro) |
Degradation analysis in a panel of other human cancer cell lines (EOL-1, A-204) confirms the potency of VZ185 (DC50 between 2 and 8 nM for BRD9). In vitro PK data further showed high stabilities of VZ185 in both plasma and microsomes from both human and mouse species, as well as high aqueous kinetic solubility (up to ~100 μM)[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
995.21 |
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Formula |
C53H67FN8O8S |
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CAS 号 |
2306193-61-1 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 200 mg/mL (200.96 mM; Need ultrasonic) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
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参考文献 |
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