Kisspeptin-10, human TFA(Synonyms: 亲吻促动素-10三氟乙酸盐(人源))

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Kisspeptin-10, human TFA (Synonyms: 亲吻促动素-10三氟乙酸盐(人源)) 纯度: 98.10%

Kisspeptin-10, human TFA 是一种有效的血管收缩剂和血管生成抑制剂。Kisspeptin-10, human TFA 通过其受体 GPR54 来抑制肿瘤转移作用。Kisspeptin-10-GPR54 系统在胚胎肾脏发育中起重要作用。Kisspeptin-10/GPR54 信号通过 NFATc4 介导的 BMP2 表达来诱导成骨细胞分化。

Kisspeptin-10, human TFA(Synonyms: 亲吻促动素-10三氟乙酸盐(人源))

Kisspeptin-10, human TFA Chemical Structure

规格 价格 是否有货 数量
1 mg ￥1200 In-stock
5 mg ￥4100 In-stock
10 mg   询价  
50 mg   询价  

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生物活性

Kisspeptin-10, human TFA is a potent vasoconstrictor and inhibitor of angiogenesis. Kisspeptin-10, human TFA acts as a tumor metastasis suppressor via its receptor GPR54. Kisspeptin-10-GPR54 system plays an important role in embryonic kidney development. Kisspeptin-10/GPR54 signaling induces osteoblast differentiation via NFATc4-mediated BMP2 expression[1].

IC50 & Target

GPR54[1]
Angiogenesis[1]
体外研究
(In Vitro)

Kisspeptin-10 (KP-10) and its receptor GPR54 are key components in the regulation of GnRH secretion in humans and other mammals. Kisspeptin-10 protein binds to GPR54. Activation of Kisspeptin-10 suppresses pulmonary human melanoma and Kisspeptin-10 is a metastasis suppressor in breast cancer cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Intravenous infusion of kisspeptin-10 (7.5, 35, and 100 nM) induces a dose-dependent increase in LH secretion. The stimulatory effect of kisspeptin-10 (100 n nM) on LH secretion is blocked by the GnRH antagonist cetrorelix, precluding a singular action on gonadotropes[4]. Kisspeptin-10 inhibits angiogenesis in vivo. Kp-10 inhibits tumor growth in SCID mice xenografted with human prostate cancer cells (PC-3) through inhibiting tumor angiogenesis[5].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1416.46

Formula

C63H83N17O14.C2HF3O2
Sequence

Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
Sequence Shortening

YNWNSFGLRF-NH2
中文名称

亲吻促动素-10三氟乙酸盐(人源)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (70.60 mM; Need ultrasonic)

H2O : 4 mg/mL (2.82 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.7060 mL 3.5299 mL 7.0599 mL
5 mM 0.1412 mL 0.7060 mL 1.4120 mL
10 mM 0.0706 mL 0.3530 mL 0.7060 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Son HE, et al. Kisspeptin-10 (KP-10) stimulates osteoblast differentiation through GPR54-mediated regulation of BMP2 expression and activation. Sci Rep. 2018 Feb 1;8(1):2134.

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