MC-Val-Ala-PAB-PNP

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MC-Val-Ala-PAB-PNP  纯度: 99.34%

MC-Val-Ala-PAB-PNP 是一种可降解 (cleavable) 的 ADC linker,可用于合成抗体偶联药物 (ADC)。

MC-Val-Ala-PAB-PNP

MC-Val-Ala-PAB-PNP Chemical Structure

CAS No. : 1639939-40-4

规格 价格 是否有货 数量
10 mg ¥4500 In-stock
50 mg ¥12500 In-stock
100 mg   询价  
200 mg   询价  

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生物活性

MC-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target

Cleavable

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

651.66

Formula

C32H37N5O10

CAS 号

1639939-40-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶解性数据
In Vitro: 

DMSO : 50 mg/mL (76.73 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.5345 mL 7.6727 mL 15.3454 mL
5 mM 0.3069 mL 1.5345 mL 3.0691 mL
10 mM 0.1535 mL 0.7673 mL 1.5345 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

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