Solasodine(Synonyms: Purapuridine; Solancarpidine; Solasodin)

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Solasodine (Synonyms: Purapuridine; Solancarpidine; Solasodin) 纯度: 98.86%

Solasodine (Purapuridine) 是类固醇生物碱，存在于茄科植物中。Solasodine 具有神经保护，抗真菌，降压，抗癌，抗动脉粥样硬化，抗雄激素和抗炎活性。

Solasodine(Synonyms: Purapuridine; Solancarpidine; Solasodin)

Solasodine Chemical Structure

CAS No. : 126-17-0

规格 价格 是否有货 数量
10 mg ￥600 In-stock
50 mg ￥1500 In-stock
100 mg ￥2600 In-stock
200 mg   询价  
500 mg   询价  

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生物活性

Solasodine (Purapuridine) is a steroidal alkaloid that occurs in plants of the Solanaceae family. Solasodine has neuroprotective, antifungal, hypotensive, anticancer, antiatherosclerotic, antiandrogenic and anti-inflammatory activities[1][2].

体外研究
(In Vitro)

Solasodine (90 μM; 2 days) treatment displays significant sprouting in P19 cells. Solasodine induces strong expression of the different neuronal markers studied, including βIII-tubulin, synaptophysin, MAP2, ChAT, and neuroblast marker doublecortin. Solasodine induces the differentiation of P19 cells, essentially towards the neuronal pathway[1]. Solasodine induce apoptosis by inhibiting the p53-MDM2 complex, p21Waf1/Cip1, and Bcl-2 proteins[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Solasodine (25-100 mg/kg; intraperitoneal injection; once) treatment significantly delays latency of hind limb tonic extensor (HLTE) phase in the PCT-induced convulsions. And significantly potentiates Thiopental-provoked sleep in a dose-dependent manner. Solasodine has anticonvulsant and CNS depressant activities[2].
Solasodine (375 μM; i.c.v.; for 2 weeks) treatment results a significant increase in bromodeoxyuridine uptake by cells of the ependymal layer, subventricular zone, and cortex that co-localized with doublecortin immunostaining. Solasodine treatment in rats results in a dramatic increase in expression of the cholesterol- and drug-binding translocator protein in ependymal cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss albino mice (18-25 g) treated with Picrotoxin (PCT) or Thiopental[2]
Dosage: 25 mg/kg, 50 mg/kg and 100 mg/kg
Administration: Intraperitoneal injection; once
Result: Significantly delayed latency of hind limb tonic extensor (HLTE) phase in the PCT-induced convulsions. And significantly potentiated Thiopental-provoked sleep in a dose-dependent manner.

Clinical Trial

分子量

413.64

Formula

C27H43NO2
CAS 号

126-17-0
中文名称

澳洲茄胺；澳洲茄铵；茄解啶；茄解鹼；澳洲茄次碱
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性数据
In Vitro: 

DMSO : 2.6 mg/mL (6.29 mM; Need ultrasonic)

H2O : 0.67 mg/mL (1.62 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.4176 mL 12.0878 mL 24.1756 mL
5 mM 0.4835 mL 2.4176 mL 4.8351 mL
10 mM — — —

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Lecanu L, et al. The naturally occurring steroid solasodine induces neurogenesis in vitro and in vivo. Neuroscience. 2011 Jun 2;183:251-64.

    [2]. Chauhan K, et al. Anticonvulsant activity of solasodine isolated from Solanum sisymbriifolium fruits in rodents. Pharm Biol. 2011 Feb;49(2):194-9.

    [3]. Akhtar S, et al. Evaluation and Elucidation Studies of Natural Aglycones for Anticancer Potential using Apoptosis-Related Markers: An In silico Study. Interdiscip Sci. 2018 Jun;10(2):297-310.

    [4]. Gupta RS, et al. Effects of short-term treatment of solasodine on cauda epididymis in dogs. Indian J Exp Biol. 2002 Feb;40(2):169-73.

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