上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
BI 99179 纯度: 99.78%
BI 99179 是一种有效的选择性 I 型脂肪酸合成酶 (FAS) 抑制剂,IC50 为 79 nM。BI 99179 是一种适用于体内验证 FAS 作为脂质代谢相关疾病的靶点的工具化合物。在大鼠中口服 BI 99179 表现出显着的外周和中央暴露。
BI 99179 Chemical Structure
CAS No. : 1291779-76-4
规格 | 价格 | 是否有货 | 数量 |
---|---|---|---|
5 mg | ¥2000 | In-stock | |
10 mg | ¥3200 | In-stock | |
50 mg | ¥9500 | In-stock | |
100 mg | ¥15000 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
* Please select Quantity before adding items.
BI 99179 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Metabolism/Protease Compound Library
- Anti-Cancer Compound Library
- Chemical Probe Library
- Anti-Cancer Metabolism Compound Library
- Anti-Obesity Compound Library
- Lipid Metabolism Compound Library
生物活性 |
BI 99179 is a potent and selective type I fatty acid synthase (FAS) inhibitor with an IC50 of 79 nM. BI 99179 is a tool compound suitable for the in vivo validation of FAS as a target for lipid metabolism related diseases. BI 99179 exhibits significant exposure (both peripheral and central) upon oral administration in rats[1][2]. |
IC50 & Target |
IC50: 79 nM (FASN)[1] |
||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
体外研究 (In Vitro) |
BI 99179 is potent in the mouse hypothalamic N-42 cell with an IC50 of 0.6 μM. BI 99179 shows no significant LDH release in the cytotoxicity assay up to 30 μM[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation Assay[2]
|
||||||||||||||||
体内研究 (In Vivo) |
BI 99179 has a super pharmacokinetic profile in male Han/Wistar rats (oral application of 4 mg/kg) with half life (t1/2) of 3.0 h[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
||||||||||||||||
分子量 |
391.46 |
||||||||||||||||
Formula |
C23H25N3O3 |
||||||||||||||||
CAS 号 |
1291779-76-4 |
||||||||||||||||
运输条件 |
Room temperature in continental US; may vary elsewhere. |
||||||||||||||||
储存方式 |
|
||||||||||||||||
溶解性数据 |
In Vitro:
DMSO : 125 mg/mL (319.32 mM; Need ultrasonic) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
|
||||||||||||||||
参考文献 |
|
所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务