上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
Ilaprazole (Synonyms: 艾普拉唑; IY-81149) 纯度: ≥98.0%
Ilaprazole (IY-81149),一种具有口服活性质子泵抑制剂,以剂量依赖性方式不可逆地抑制 H+/K+-ATPase,在兔壁细胞制剂中的 IC50 为 6 μM。Ilaprazole 用于胃溃疡的研究。Ilaprazole 也是一种有效的T细胞起源蛋白激酶 (TOPK) 抑制剂。
Ilaprazole Chemical Structure
CAS No. : 172152-36-2
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10 mM * 1 mL in DMSO | ¥1209 | In-stock | |
2 mg | ¥900 | In-stock | |
5 mg | ¥1500 | In-stock | |
10 mg | ¥2400 | In-stock | |
50 mg | ¥8500 | In-stock | |
100 mg | ¥14000 | In-stock | |
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Ilaprazole 相关产品
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生物活性 |
Ilaprazole (IY-81149) is an orally active proton pump inhibitor. Ilaprazole irreversibly inhibits H+/K+-ATPase in a dose-dependent manner with an IC50 of pump inhibitory activity of 6 μM in rabbit parietal cell preparation. Ilaprazole is used for the research of gastric ulcers. Ilaprazole is also a potent TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor[1][2]. |
IC50 & Target |
IC50: 6.0 μM (H+/K+-ATPase)[1] |
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体外研究 (In Vitro) |
On cumulation of 14C-aminopyrine in histamine stimulated parietal cells, the IC50 of Ilaprazole (IY-81149) sodium is 9 nM[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
Ilaprazole (3-30 mg/kg; i.d.) dose-dependently inhibits gastric acid secretion[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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Clinical Trial |
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分子量 |
366.44 |
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Formula |
C19H18N4O2S |
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CAS 号 |
172152-36-2 |
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中文名称 |
艾普拉唑 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : ≥ 35 mg/mL (95.51 mM) Ethanol : 12.5 mg/mL (34.11 mM; Need ultrasonic) * “≥” means soluble, but saturation unknown. 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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