BOS-172722

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

BOS-172722  纯度: 99.44%

BOS-172722 是单极纺锤体 1 (MPS1) 检查点的抑制剂，其 对MPS1 (1 mM ATP) 和P-MPS1 的 IC50 值分别为 11 nM 和 63 nM。BOS-172722 可用于多种乳腺癌的研究。

BOS-172722

BOS-172722 Chemical Structure

CAS No. : 1578245-44-9

规格 价格 是否有货 数量
5 mg ￥2200 In-stock
10 mg ￥3300 In-stock
25 mg ￥6600 In-stock
50 mg ￥9900 In-stock
100 mg ￥14000 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

BOS-172722 相关产品

•相关化合物库:

  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus

生物活性

BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint with an IC50 of 11 nM and 63 nM for MPS1 (1 mM ATP) and P-MPS1, respectively. BOS-172722 also has potential for the study of various forms of breast cancer[1].

IC50 & Target

2 nM (MPS1)[1].
体外研究
(In Vitro)

BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint with an IC50 of 2 nM. BOS-172722 also has potential for the treatment of various forms of breast cancer[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

BOS-172722 shows excellent PK in mouse, rat, and dog[1].
BOS-172722 (50 mg/kg) results in an increased suppression of MPS1 autophosphorylation at 6 and 24 h[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Dog[2].
Dosage: 1 mg/kg (iv), 5 mg/kg (po) (Pharmacokinetic Analysis).
Administration: IV and PO.
Result: T1/2 = 12 h, Cmaxpo = 7770 nmol/L, AUCpo = 147035 h*nmol/L.

Clinical Trial

分子量

446.55

Formula

C24H30N8O
CAS 号

1578245-44-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

1M HCl : 65 mg/mL (145.56 mM; ultrasonic and adjust pH to 2 with HCl)

DMSO : 5 mg/mL (11.20 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.2394 mL 11.1970 mL 22.3939 mL
5 mM 0.4479 mL 2.2394 mL 4.4788 mL
10 mM 0.2239 mL 1.1197 mL 2.2394 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. ARYL SULFONOHYDRAZIDES. WO 2014037750 A1.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务