上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
Siramesine hydrochloride (Synonyms: 西拉美新盐酸盐; Lu 28-179 hydrochloride) 纯度: 99.85%
Siramesine (Lu 28-179) hydrochloride 是一种有效的 sigma-2 受体激动剂。Siramesine 对 sigma-2 受体具有亚纳摩尔亲和力 (IC50=0.12 nM),并且对 sigma-2 受体的选择性是 sigma-1 受体的 140 倍 (IC50=17 nM)。Siramesine hydrochloride 通过线粒体的不稳定而不是溶酶体触发细胞死亡。Siramesine hydrochloride 显示出强大的抗癌活性。
Siramesine hydrochloride Chemical Structure
CAS No. : 224177-60-0
规格 | 价格 | 是否有货 | 数量 |
---|---|---|---|
10 mM * 1 mL in DMSO | ¥2512 | In-stock | |
2 mg | ¥1550 | In-stock | |
5 mg | ¥2325 | In-stock | |
10 mg | ¥3534 | In-stock | |
50 mg | ¥8370 | In-stock | |
100 mg | ¥13020 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
* Please select Quantity before adding items.
Siramesine hydrochloride 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Apoptosis Compound Library
- GPCR/G Protein Compound Library
- Neuronal Signaling Compound Library
- Anti-Cancer Compound Library
- Ferroptosis Compound Library
- FDA Approved & Pharmacopeial Drug Library
- Neuroprotective Compound Library
- Anti-Parkinson’s Disease Compound Library
- Neurodegenerative Disease-related Compound Library
- Targeted Diversity Library
生物活性 |
Siramesine (Lu 28-179) hydrochloride is a potent sigma-2 receptor agonist. Siramesine hydrochloride has a subnanomolar affinity for sigma-2 receptors (IC50=0.12 nM) and exhibits a 140-fold selectivity for sigma-2 receptors over sigma-1 receptors (IC50=17 nM). Siramesine hydrochloride triggers cell death through destabilisation of mitochondria, but not lysosomes. Anti-cancer activity[1][2][3]. |
||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
体外研究 (In Vitro) |
Siramesine hydrochloride displays the binding affinities: IC50 (sigma 1)=17 nM, IC50 (sigma 2)=0.12 nM, IC50 (5-HT1A)=21000 nM, IC50 (5-HT1A)=2000 nM, IC50 (D2)=800 nM, IC50 (alpha 1)=330 nM[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
||||||||||||||||
分子量 |
491.04 |
||||||||||||||||
Formula |
C30H32ClFN2O |
||||||||||||||||
CAS 号 |
224177-60-0 |
||||||||||||||||
中文名称 |
西拉美新盐酸盐 |
||||||||||||||||
运输条件 |
Room temperature in continental US; may vary elsewhere. |
||||||||||||||||
储存方式 |
4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
||||||||||||||||
溶解性数据 |
In Vitro:
DMSO : ≥ 42 mg/mL (85.53 mM) * “≥” means soluble, but saturation unknown. 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
|
所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务