Sodium 2-mercaptoethanesulfonate(Synonyms: 美司钠; Sodium 2-mercaptoethanesulfonate; Mesnum)

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Sodium 2-mercaptoethanesulfonate (Synonyms: 美司钠; Sodium 2-mercaptoethanesulfonate; Mesnum) 纯度: ≥98.0%

Mesna (Sodium 2-mercaptoethanesulfonate) 是一种具有细胞保护作用的抗氧化剂。Mesna 广泛用作抗化学疗法毒性的全身保护剂。 Mesna 还可用于减轻由环磷酰胺引起的出血性膀胱炎。

Sodium 2-mercaptoethanesulfonate(Synonyms: 美司钠; Sodium 2-mercaptoethanesulfonate; Mesnum)

Sodium 2-mercaptoethanesulfonate Chemical Structure

CAS No. : 19767-45-4

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生物活性

Mesna (Sodium 2-mercaptoethanesulfonate) is an antioxidant which has cytoprotective effects. Mesna is widely used as a systemic protective agent against chemotherapy toxicity. Mesna is also used to reduce hemorrhagic cystitis induced by cyclophosphamide[1][2].

体外研究
(In Vitro)

Mesna (1-1000 μM) reduces H2O2, HOCl and OH• concentrations in a dose-dependent manner, with an IC50 of 32, 21, and 305 μM, respectively in cell-free experiments[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Mesna (150 mg/kg; a single i.p.) protects the rat brain against traumatic injury[1].
Mesna (200 mg/kg; a single i.p.) attenuates the cisplatin-induced ovarian damages in rats[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Wistar Albino rats (250-350 g) are suffered traumatic brain injury (TBI)[1]
Dosage: 150 mg/kg
Administration: A single i.p.
Result: Decreased tissue malondialdehyde levels.
Increased the activity of glutathione peroxidase and superoxide dismutase.
Decreased the levels of nitric oxide, nitric oxide synthetase and xanthine oxidase.
Protected the brain tissues well from injury.

分子量

164.18

Formula

C2H5NaO3S2
CAS 号

19767-45-4
中文名称

美司钠；巯乙磺酸钠
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro: 

H2O : ≥ 50 mg/mL (304.54 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 6.0909 mL 30.4544 mL 60.9088 mL
5 mM 1.2182 mL 6.0909 mL 12.1818 mL
10 mM 0.6091 mL 3.0454 mL 6.0909 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Yilmaz ER, Kertmen H, Gürer B, The protective effect of 2-mercaptoethane sulfonate (MESNA) against traumatic brain injury in rats. Acta Neurochir (Wien). 2013 Jan;155(1):141-9; discussion 149.

    [2]. Li X, Yang S, Lv X, The mechanism of mesna in protection from cisplatin-induced ovarian damage in female rats. J Gynecol Oncol. 2013 Apr;24(2):177-85.

    [3]. Gressier B, et, al. Scavenging of reactive oxygen species by letosteine, a molecule with two blocked-SH groups. Comparison with free-SH drugs. Pharm World Sci. 1995 May 26;17(3):76-80.

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