DDR1-IN-1 dihydrochloride

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DDR1-IN-1 dihydrochloride 

DDR1-IN-1 dihydrochloride是DDR1受体酪氨酸激酶抑制剂,IC50 值为105 nM,而对 DDR2 的 IC50 为413 nM。

DDR1-IN-1 dihydrochloride

DDR1-IN-1 dihydrochloride Chemical Structure

CAS No. : 1780303-76-5

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DDR1-IN-1 dihydrochloride 的其他形式现货产品:

DDR1-IN-1

生物活性

DDR1-IN-1 dihydrochloride is a potent and selective DDR1 receptor tyrosine kinase inhibitor with an IC50 of 105 nM; 4-fold less potent for DDR2 (IC50 = 413 nM)[1].

IC50 & Target

DDR1

105 nM (IC50)

DDR2

413 nM (IC50)

体外研究
(In Vitro)

DDR1-IN-1 effectively blocks collagen-induced DDR1 pY513 autophosphorylation in U2OS cells (EC50 = 86.76 nM) with excellent selectivity over a panel of >380 kinases. DDR1-IN-1 inhibits DDR2-mediated MT1-MMP activation in human rheumatoid synovial fibroblasts (RASF) upon collagen stimulation (IC50 < 2.5 μM) and enhances PI3K/mTOR inhibitor GSK2126458 antiproliferation efficacy in SNU-1040 colorectal cancer culture[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

625.51

Formula

C30H33Cl2F3N4O3

CAS 号

1780303-76-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Kim HG, et al. Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor. ACS Chem Biol. 2013 Oct 18;8(10):2145-50.

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