ERRγ Inverse Agonist 1

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ERRγ Inverse Agonist 1 

ERRγ Inverse Agonist 1 (Compound 12) 是有效的、选择性的、具有口服活性的 雌激素相关受体 γ (ERRγ) 的反向激动剂,其 IC50 值为 40 nM。

ERRγ Inverse Agonist 1

ERRγ Inverse Agonist 1 Chemical Structure

CAS No. : 2316832-86-5

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生物活性

ERRγ Inverse Agonist 1 (Compound 12) is a potent, selective and orally bioavailable Estrogen-related Receptor grammar (ERRγ) inverse agonist, with an IC50 of 40 nM[1].

IC50 & Target[1]

ERRγ

0.040 μM (IC50)

ERRβ

1.330 μM (IC50)

ERα

1.240 μM (IC50)

分子量

529.54

Formula

C30H38Cl2N2O2

CAS 号

2316832-86-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Kim J, et al. Discovery of Potent, Selective, and Orally Bioavailable Estrogen-Related Receptor-γ Inverse Agonists To Restore the Sodium Iodide Symporter Function in Anaplastic Thyroid Cancer. J Med Chem. 2019 Feb 28;62(4):1837-1858.

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